The efficacies and limitations of fasciectomy and collagenase clostridium histolyticum in Dupuytren's contracture management: A meta-analysis. (1st June 2020)

• Record Type: Journal Article
• Authors: Cooper, Tokai B; Poonit, Keshav; Yao, Chenglun; Jin, Zeyuan; Zheng, Jingwei; Yan, Hede
• Is Part Of: Journal of orthopaedic surgery. Volume 28:Number 2(2020)
• Publication Date: 2020-06-01
• Subjects: collagenase clostridium histolyticum -- Dupuytren's contracture -- efficacy -- fasciectomy; Orthopedic surgery -- Periodicals; Orthopedics; Orthopedic surgery; Periodicals; 617.3
• DOI: 10.1177/2309499020921747
• Languages: English
• ISSNs: 1022-5536

Abstract

Background: We intend to assess the efficacies and limitations of collagenase clostridium histolyticum (CCH) and fasciectomy in treating Dupuytren's contracture, and the associated complications and rate of recurrences aiming to present a treatment algorithm. Methods: A literature search within the PubMed, Web of Sciences, Cochrane Library, and EMBASE databases was performed using the combined key words 'Dupuytren, palmar aponeurosis contracture, collagenase clostridium histolyticum and fasciectomy', including all possible studies with a set of predefined inclusion and exclusion criteria. Results: Thirty studies were assessed for eligibility from 215 identified records. Seventeen publications satisfied the inclusion criteria including 2142 joints in 1784 patients. The mean follow-up time was 18.0 months (3–60). Conclusion: Acceptable contractures release was obtained in both techniques. Severe complications associated with fasciectomy outrank those of CCH, whereas the low rate of recurrence favors the fasciectomy technique.