Aggressive multiple sclerosis (2): Treatment. (August 2020)

• Record Type: Journal Article
• Authors: Arrambide, Georgina; Iacobaeus, Ellen; Amato, Maria Pia; Derfuss, Tobias; Vukusic, Sandra; Hemmer, Bernhard; Brundin, Lou; Tintore, Mar
• Other Names: Berger Joseph non-byline-author.; Boyko Alexey non-byline-author.; Brinar Vesna non-byline-author.; Brownlee Wallace non-byline-author.; Ciccarelli Olga non-byline-author.; Coles Alasdair non-byline-author.; Correale Jorge non-byline-author.; Cutter Gary non-byline-author.; Edan Gilles non-byline-author.; Evangelou Nikolaos non-byline-author.; Fernandez Oscar non-byline-author.; Frederiksen Jette non-byline-author.; Gold Ralf non-byline-author.; Hacohen Yael non-byline-author.; Hartung Hans-Peter non-byline-author.; Hellwig Kerstin non-byline-author.; Hillert Jan non-byline-author.; Imitola Jaime non-byline-author.; Kalincik Tomas non-byline-author.; Kappos Ludwig non-byline-author.; Khoury Samia non-byline-author.; Kim Ho Jin non-byline-author.; Havrdová Eva Kubala non-byline-author.; Liblau Roland non-byline-author.; Lycke Jan non-byline-author.; Montalban Xavier non-byline-author.; Muraro Paolo non-byline-author.; Reingold Stephen non-byline-author.; Schmierer Klaus non-byline-author.; Sellebjerg Finn non-byline-author.; Sørensen Per Soelberg non-byline-author.; Solari Alessandra non-byline-author.; Sormani Maria Pia non-byline-author.; Thompson Alan non-byline-author.; Trapp Bruce non-byline-author.; Tremlett Helen non-byline-author.; Trojano Maria non-byline-author.; Tur Carmen non-byline-author.; Uccelli Antonio non-byline-author.; van Pesch Vincent non-byline-author.; Waubant Emmanuelle non-byline-author.;
• Is Part Of: Multiple sclerosis. Volume 26:Number 9(2020)
• Page Start: 1045
• Page End: 1063
• Publication Date: 2020-08
• Subjects: Aggressive -- highly active -- multiple sclerosis -- disability -- relapsing–remitting -- treatment response; Central nervous system -- Diseases -- Periodicals; Myelin sheath -- Diseases -- Periodicals; Inflammation -- Periodicals; Multiple sclerosis -- Periodicals; Central Nervous System Diseases -- Periodicals; Demyelinating Diseases -- Periodicals; Inflammation -- Periodicals; Multiple Sclerosis -- Periodicals; Système nerveux central -- Maladies -- Périodiques; Gaine de myéline -- Maladies -- Périodiques; Inflammation (Pathologie) -- Périodiques; Sclérose en plaques -- Périodiques; Electronic journals; 616.834005
• DOI: 10.1177/1352458520924595
• Languages: English
• ISSNs: 1352-4585

Abstract

The natural history of multiple sclerosis (MS) is highly heterogeneous. A subgroup of patients has what might be termed aggressive MS. These patients may have frequent, severe relapses with incomplete recovery and are at risk of developing greater and permanent disability at the earlier stages of the disease. Their therapeutic window of opportunity may be narrow, and while it is generally considered that they will benefit from starting early with a highly efficacious treatment, a unified definition of aggressive MS does not exist and data on its treatment are largely lacking. Based on discussions at an international focused workshop sponsored by the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS), we review our current knowledge about treatment of individuals with aggressive MS. We analyse the available evidence, identify gaps in knowledge and suggest future research needed to fill those gaps. A companion paper details the difficulties in developing a consensus about what defines aggressive MS.