Mechanistic insights of adipocyte metabolism in regulating breast cancer progression. (May 2020)

• Record Type: Journal Article
• Authors: Zhang, Fuchuang; Liu, Suling
• Is Part Of: Pharmacological research. Volume 155(2020)
• Publication Date: 2020-05
• Subjects: BCSCs breast cancer stem cells -- CLS Crown-like structures -- ROS reactive oxygen species -- IGF-1 insulin-like growth factor-1 -- TNFα tumor necrosis factor α -- HIF1α hypoxia-inducible factor 1α -- IL6 Interleukin 6 -- IL1β Interleukin-1 beta -- TAMs tumor-associated macrophages -- MDSCs myeloid-derived suppressor cells -- NK natural killer -- TILs tumor infiltrating lymphocytes -- iNKT invariant natural killer T -- Tregs the regulatory T cells -- Th2 T helper 2 -- Th1 T helper 1 -- IFNγ interferon γ -- IL4 interleukin 4 -- IL13 interleukin 13 -- IL10 interleukin 10 -- IL8 interleukin 8 -- NF-κB nuclear factor kappa B -- MCP1 monocyte chemoattractant protein 1 -- ER estrogen receptor -- TGFβ transforming growth factor β -- VEGF vascular endothelial growth factor -- CCL2 C-C motif chemokine ligand 2 -- CXCL12 C-X-C motif chemokine 12 -- MAPK A mitogen-activated protein kinase -- JAK janus kinase -- STAT signal transducer and activator of transcription -- NOS nitric oxide synthase -- COX2 cyclooxygenase 2 -- RAR the retinoic acid receptor -- AP-1 activator protein 1 -- PI3K phosphoinositide 3-kinase -- AMPK AMP-activated protein kinase -- TNBC triple-negative breast cancer -- CCR2 C-C chemokine receptor type 2 -- ARG1 arginase 1 -- PD-1 programmed cell death-1 -- Foxp3 forkhead box P3; Adipocyte -- Breast cancer -- Breast cancer therapy; Pharmacology -- Periodicals; Pharmacology -- Periodicals; Research -- Periodicals; Médicaments -- Recherche -- Périodiques; Pharmacologie -- Périodiques; 615.105
• DOI: 10.1016/j.phrs.2020.104741
• Languages: English
• ISSNs: 1043-6618

Abstract

Graphical abstract: Abstract: Adipocyte account for the largest component in breast tissue. Dysfunctional adipocyte metabolism, such as metaflammation in metabolically abnormal obese patients, will cause hyperplasia and hypertrophy of its constituent adipocytes. Inflamed adipose tissue is one of the biggest risk factors causing breast cancer. Factors linking adipocyte metabolism to breast cancer include dysfunctional secretion of proinflammatory mediators, proangiogenic factors and estrogens. The accumulation of tumor supporting cells and systemic effects, such as insulin resistance, dyslipidemia and oxidative stress, which are caused by abnormal adipocyte metabolism, further contribute to a more aggressive tumor microenvironment and stimulate breast cancer stem cell to influence the development and progression of breast cancer. Here, in this review, we focus on the adipocyte metabolism in regulating breast cancer progression, and discuss the potential targets which can be used for breast cancer therapy.