Medicopsis romeroi nodular subcutaneous infection in a kidney transplant recipient. (June 2020)

• Record Type: Journal Article
• Authors: Jeddi, Fakhri; Paugam, Charlotte; Hartuis, Sophie; Denis-Musquer, Marie; Sabou, Marcela; Lavergne, Rose-Anne; Muguet, Louise; Le Pape, Patrice
• Is Part Of: International journal of infectious diseases. Volume 95(2020)
• Page Start: 262
• Page End: 264
• Publication Date: 2020-06
• Subjects: Phaeohyphomycosis -- Medicopsis romeroi -- Renal transplant -- Triazoles -- Surgical excision; Communicable diseases -- Periodicals; Communicable Diseases -- Periodicals; Communicable diseases; Periodicals; Electronic journals; 616.9
• DOI: 10.1016/j.ijid.2020.04.028
• Languages: English
• ISSNs: 1201-9712

Abstract

Abstract: Phaeohyphomycosis is a set of fungal infections caused by various dematiaceous fungi such as coelomycetes. These infections can occur either in immunocompetent or immunocompromised patients like solid organ transplants. Here we describe a nodular lesion of the right hallux that occurred in a kidney transplant patient. Microscopic examination of the biopsy revealed fungal hyphae and culture was positive to a grey to black mould that lacked characteristic elements to be identified. Nucleic acid sequencing targeting the internal transcribed spacer of the ribosomal DNA identified this mould as Medicopsis romeroi . The patient benefited of an antifungal therapy with voriconazole associated with surgical excision of the lesion. No relapse of the lesion was observed during a six-month follow-up. In solid organ transplants, phaeohyphomycosis caused by Medicopsis romero i are very rare with only 12 cases reported. The clinical history should be well assessed since the lesion can appear several years after a cutaneous trauma that happened in a tropical region. Therapy generally combines antifungals with surgical excision of the lesion in order to avoid any relapse or dissemination of the infection.