Production of liposomes loaded alginate aerogels using two supercritical CO2 assisted techniques. Issue 39 (July 2020)

• Record Type: Journal Article
• Authors: Trucillo, Paolo; Cardea, Stefano; Baldino, Lucia; Reverchon, Ernesto
• Is Part Of: Journal of CO₂ utilization. Issue 39(2020)
• Publication Date: 2020-07
• Subjects: Liposomes -- Aerogel -- Supercritical CO2 -- Drug carrier -- Prolonged release; Carbon dioxide -- Periodicals; Carbon dioxide -- Environmental aspects -- Periodicals; Carbon dioxide mitigation -- Periodicals; Carbon dioxide; Carbon dioxide -- Environmental aspects; Carbon dioxide mitigation; Periodicals; 628.53205
• DOI: 10.1016/j.jcou.2020.101161
• Languages: English
• ISSNs: 2212-9820

Abstract

Graphical abstract: Highlights: Ampicillin loaded liposomes were entrapped in alginate aerogels to create a meta-carrier. SuperLip favored the production of liposomes at nanometric level. Alginate gel nanoporous structure was preserved by supercritical drying. Ampicillin release time from meta-carriers was twice than its release from liposomes alone. Abstract: Ampicillin loaded liposomes were entrapped in alginate aerogels to create a meta-carrier (a carrier within another carrier), to obtain a prolonged drug release. Liposomes with a diameter of 200 ± 77 nm and with an encapsulation efficiency of 69.5 ± 1.2% were produced using a supercritical assisted formation process (SuperLip). Then, they were entrapped into alginate gels, and the final loaded aerogels were obtained by supercritical CO2 drying. The successful entrapment of liposomes into aerogels was confirmed by EDX analysis. Drug release tests demonstrated that ampicillin release time from these meta-carriers was about 4 days; i.e., about twice than its release time from liposomes alone. Two mass transfer resistances in series operated in the overall drug release: one related to liposomes lipidic layers and one due to the presence of the alginate aerogel matrix.