Is brain perfusion a differentiating feature in the comparison of Progressive Supranuclear Palsy Syndrome (PSPS) and Corticobasal Syndrome (CBS)?. (July 2020)

• Record Type: Journal Article
• Authors: Alster, Piotr; Nieciecki, Michał; Koziorowski, Dariusz; Cacko, Andrzej; Charzyńska, Ingeborga; Królicki, Leszek; Friedman, Andrzej
• Is Part Of: Journal of clinical neuroscience. Volume 77(2020)
• Page Start: 123
• Page End: 127
• Publication Date: 2020-07
• Subjects: ASL arterial spin labeling -- CBD corticobasal degeneration -- CBS corticobasal syndrome -- CT Computed Tomography -- DMFP desmethoxyfallypride -- 18F-FDG-PET fluorodeoxyglucose positron emission tomography -- HMPAO hexamethylpropyleneamine oxime -- 123IBZM iodobenzamide -- LEHR low energy high resolution -- MRI magnetic resonance imaging -- MSA multiple system atrophy -- PET positron emission tomography -- PSP progressive supranuclear palsy -- PSP-P progressive supranuclear palsy resembling idiopathic Parkinson's disease -- PSP-RS progressive supranuclear palsy – Richardson's syndrome -- PSPS progressive supranuclear palsy syndrome -- ROI region of interest -- SPECT single photon emission computed tomography -- SD standard deviation; PSP -- CBS -- rCBF -- SPECT -- Hypoperfusion; Brain -- Surgery -- Periodicals; Neurosciences -- Periodicals; Nervous system -- Surgery -- Periodicals; Brain -- surgery -- Periodicals; Neurosurgical Procedures -- Periodicals; Neurosciences -- Periodicals; Electronic journals; 616.8
• DOI: 10.1016/j.jocn.2020.05.005
• Languages: English
• ISSNs: 0967-5868

Abstract

Highlights: PSP and CBS are clinical manifestations of 4R tauopathies. Differentiation of these entities remains a difficult issue. Brain perfusion of the syndromes shows significant overlaps. Boundary of PSP and CBS is questionable. Abstract: The aim of this work is to present whether SPECT 99m Tc-HMPAO can be a method of examination to possibly differentiate the syndromes. 21 patients with PSP syndrome and 14 patients with corticobasal syndrome (CBS) were examined using SPECT 99m Tc-HMPAO. Perfusion single photon emission computed tomography (SPECT) as a method of examination of progressive supranuclear palsy (PSP) and corticobasal syndrome (CBS) has not been extensively analyzed in contemporary literature. Recent criteria of PSP and CBS do not describe this method of examination as primary or additional. Extended analysis was done in the context of regions of interest affected by significant average hypoperfusion (>2 standard deviations). Differences between the syndromes were subsequently evaluated using the U-Mann-Whitney test. Lack of significant differences (p < 0.05) were observed in 92 out of 94 regions of interest. However, certain asymmetries were observed in a minority of regions in both of the syndromes. Additionally, the authors of the study verified possible differences of asymmetry of perfusion of both of the syndromes. The overlapping of clinical manifestations and locations of hypoperfusion leads to a question of whether the syndromes should be interpreted as separate entities or variants of the same disease.