Multiple facets of TRPML1 in autophagy. (June 2020)

• Record Type: Journal Article
• Authors: Huang, Peng; Xu, Mengnan; Wu, Yi; Rizvi Syeda, Alia Kazim; Dong, Xian-Ping
• Is Part Of: Cell calcium. Volume 88(2020)
• Publication Date: 2020-06
• Subjects: TRPML1 -- Lysosome -- Autophagy -- mTORC1; Calcium -- Metabolism -- Periodicals; Vertebrates -- Physiology -- Periodicals; Calcium -- Physiological effect -- Periodicals; Cell physiology -- Periodicals; Calcium in the body -- Periodicals; 572.516
• DOI: 10.1016/j.ceca.2020.102196
• Languages: English
• ISSNs: 0143-4160

Abstract

Graphical abstract: Schematic overview of the role of TRPML1 in autophagy. Abstract: Autophagy is an evolutionarily conserved pathway that is required for cellular homeostasis, growth and survival. In a recent study, Scotto-Rosato et al. demonstrate that TRPML1-mediated calcium release promotes autophagosome biogenesis by activating the CaMKKβ/VPS34 pathway, providing a new insight into the pathophysiological role of TRPML1 in human diseases.