Bioorthogonal-targeted 1064 nm excitation theranostic nanoplatform for precise NIR-IIa fluorescence imaging guided efficient NIR-II photothermal therapy. (June 2020)

• Record Type: Journal Article
• Authors: Zhang, Wansu; Deng, Weixing; Zhang, Hua; Sun, Xiaoli; Huang, Ting; Wang, Wenjun; Sun, Pengfei; Fan, Quli; Huang, Wei
• Is Part Of: Biomaterials. Volume 243(2020:Jun.)
• Publication Date: 2020-06
• Subjects: NIR-IIa fluorescence imaging -- NIR-II photothermal therapy -- Bioorthogonal labelling -- Theranostic nanoplatform -- Precision medicine; Biomedical materials -- Periodicals; Biocompatible Materials -- Periodicals; Biomatériaux -- Périodiques; 610.28
• DOI: 10.1016/j.biomaterials.2020.119934
• Languages: English
• ISSNs: 0142-9612

Abstract

Abstract: Application of 1064 nm activatable NIR-IIa fluorescence imaging (FI) and NIR-II photothermal therapy (PTT) results in high-resolution imaging and good deep-tissue therapy, respectively. Combining NIR-IIa FI with NIR-II PTT may allow precise diagnosis guided efficient treatment of deep-tissue tumors. However, designing a 1064 activatable theranostic nanoplatform using a single dye for both NIR-IIa FI and NIR-II PTT is a challenge. Herein, we synthesized squaraine-based semiconducting polymer nanoparticles (PSQPNs-DBCO) that were excited by a 1064 nm laser for precise NIR-IIa fluorescence imaging guided NIR-II PTT treatment. Combined with bioorthogonal labeling technology, the PSQPNs-DBCO largely accumulated in the tumor section, extremely enhancing signal-to-background ratio (SBR) of imaging and NIR-II PTT efficiency of tumor in live colorectal-bearing animals. Graphical abstract: Image 1