Q-fever prosthetic valve endocarditis in a patient with SLE and antiphospholipid antibody syndrome. Issue 5 (May 2020)

• Record Type: Journal Article
• Authors: Alabdely, Mayyadah H.; Mukhtar, Noha; Alshaikh, Ahmad; Halim, Magid; Mohammed, Shmayel; Pragliola, Claudio; Omrani, Ali S.
• Is Part Of: Journal of infection and public health. Volume 13:Issue 5(2020)
• Page Start: 821
• Page End: 823
• Publication Date: 2020-05
• Subjects: Q fever -- Coxiella burnetii -- SLE -- Antiphospholipid -- Endocarditis; Communicable diseases -- Periodicals; Public health -- Periodicals; Epidemiology -- Periodicals; Nosocomial infections -- Prevention -- Periodicals; Medical microbiology -- Periodicals; 614.4
• DOI: 10.1016/j.jiph.2020.02.036
• Languages: English
• ISSNs: 1876-0341

Abstract

Abstract: Q fever prosthetic valve endocarditis in association with antiphospholipid antibody syndrome (APS) in systemic lupus erythematosus (SLE) has not been previously reported. Here, we report a 22-year-old Saudi female diagnosed with SLE and APS. She had mitral valve replacement with bio-prosthesis five years earlier for Libman–Sack endocarditis. She presented with two months' history of fever, cough, palpitations, and progressive shortness of breath. A transthoracic echocardiogram showed a degenerative mitral valve prosthesis with a large mass causing severe obstruction. Open heart surgery revealed multiple masses on the mitral valve. PCR from the resected tissues was positive for Coxiella burnetii DNA. Q fever serology showed phase two IgG 1:2048, phase one IgG 1:512, and IgM 1:1024. The valve was replaced with a bio-prosthesis. She was well at 12 months of follow-up.