Gastric adenocarcinoma appearance in leiomyoma: A case report. (2020)

• Record Type: Journal Article
• Authors: Wada, Kaoru; Tazawa, Hirofumi; Komo, Toshiaki; Hadano, Naoto; Onoe, Takashi; Sudo, Takeshi; Shimizu, Yosuke; Kuraoka, Kazuya; Suzuki, Takahisa; Tashiro, Hirotaka
• Is Part Of: International journal of surgery case reports. Volume 71(2020)
• Page Start: 327
• Page End: 330
• Publication Date: 2020
• Subjects: SMT submucosal tumor -- EGD esophagogastroduodenoscopy -- EUS endoscopic ultrasonography -- CEA carcinoembryonic antigen -- CA 19-9 cancer antigen 19-9 -- CT computed tomography -- sHGG solitary heterotopic gastric gland -- GIST gastrointestinal stromal tumor; Solitary heterotopic gastric gland -- Adenocarcinoma in leiomyoma; Surgery -- Periodicals; Surgical Procedures, Operative -- Periodicals; Surgery; Electronic journals; Periodicals; 617.005
• DOI: 10.1016/j.ijscr.2020.05.050
• Languages: English
• ISSNs: 2210-2612

Abstract

Highlights: Gastric adenocarcinoma arising from a leiomyoma which is diagnosed by pathological evidence as heterotopic glands carcinoma within it. Pathological evidences diagnosed heterotopic gastric glands within the leiomyoma, then adenocarcinoma arose from the heterotopic gastric glands. This is the first report that describes a case of gastric adenocarcinoma arising from leiomyoma. Abstract: Introduction: We experienced an extremely rare case of gastric adenocarcinoma wrapped by leiomyoma. Presentation of case: A 65-year-old man had an abnormality (filling defect) of the upper gastrointestinal series in his first medical checkup five years prior. Esophagogastroduodenoscopy detected a 10 mm submucosal tumor-like lesion in the greater curvature of the upper gastric remnant body. Despite repeated biopsy from the lesion, there was no sign of malignancy. A delle was observed on the top of the tumor at another visit five year after the first and a biopsy specimen revealed poorly differentiated adenocarcinoma. Therefore, laparoscopic gastrectomy was performed. Histological assessment revealed a 28 × 22 mm elevated lesion with a slight depression. Microscopically, papillary adenocarcinoma was observed at the submucosa with a solitary heterotopic gastric gland adjacent to the lesion. The final diagnosis was papillary adenocarcinoma arising from a solitary heterotopic gastric gland in the leiomyoma. No recurrence has occurred during a follow-up of two and a half years after surgery. Conclusions: This is the first report of gastric adenocarcinoma arising from a submucosal tumor.