An effective method to produce 7-epitaxol from taxol in HCO3–. Issue 15 (1st August 2020)

• Record Type: Journal Article
• Authors: Liu, Yanjie; Ma, Xiaoyu; Zhou, Mengkai; Hao, Xiaoran; Zhu, Xudong
• Is Part Of: Bioorganic & medicinal chemistry letters. Volume 30:Issue 15(2020)
• Publication Date: 2020-08-01
• Subjects: 7-Epitaxol -- Epimerization -- Taxol -- HCO3– -- Acetonitrile; Bioorganic chemistry -- Periodicals; Pharmaceutical chemistry -- Periodicals; 572
• DOI: 10.1016/j.bmcl.2020.127285
• Languages: English
• ISSNs: 0960-894X

Abstract

Graphical abstract: Abstract: It is known that 7-epitaxol has much stronger cytotoxicity than taxol does. However, the content of 7-epitaxol in yew is much less than taxol, which makes it more costly to obtain. We describe here a method to effectively convert taxol to 7-epitaxol. The key condition for reaction needs NaHCO3 in solvent acetonitrile (ACN). The conversion rate can be over 82%.