Desymmetrization construction of chiral lactones by synergistic Cu(II) complex and organic base. Issue 29 (16th July 2020)

• Record Type: Journal Article
• Authors: Ali, Murad; Li, Changkun
• Is Part Of: Tetrahedron letters. Volume 61:Issue 29(2020)
• Publication Date: 2020-07-16
• Subjects: Desymmetrization -- All-carbon quaternary center -- Copper -- Lactone -- Synergistic catalysis; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2020.152106
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Highlights: Construction of quaternary carbon center by the desymmetrization strategy. Chiral enol lactones with up to 95% ee could be synthesized from prochiral dialkynoic acid. Synergistic catalysis by chiral Cu(II) complex and chiral (DHQ)2 -PHAL base. Abstract: A highly enantioselective construction of quaternary carbon center has been realized by the desymmetrization strategy. Chiral enol lactones with up to 95% ee could be synthesized from prochiral dialkynoic acid under the catalysis of synergistic chiral Cu(II) complex and chiral (DHQ)2 -PHAL base.