Limited joint mobility of the hand correlates incident hospitalisation with infection in patients with type 2 diabetes. (March 2020)

• Record Type: Journal Article
• Authors: Mineoka, Yusuke; Ishii, Michiyo; Hashimoto, Yoshitaka; Hata, Shinnosuke; Tominaga, Hiroyuki; Nakamura, Naoto; Katsumi, Yasukazu; Fukui, Michiaki
• Is Part Of: Diabetes research and clinical practice. Volume 161(2020)
• Publication Date: 2020-03
• Subjects: Screening -- Infection -- Type 2 diabetes -- Diabetic complications -- Hand conditions -- Indicators; Diabetes -- Periodicals; Diabetes Mellitus -- Periodicals; 616.462
• DOI: 10.1016/j.diabres.2020.108049
• Languages: English
• ISSNs: 0168-8227

Abstract

Highlights: Limited joint mobility (LJM) of hand is associated with diabetic complications. The association between LJM of hand and incident hospitalisation with infection is unclear. During 3.3 years follow-up, 11.2% of patients were hospitalised with infection. LJM of the hand was associated with an increased risk of incident hospitalisation. Abstract: Aim: Limited joint mobility (LJM) of the hand is one of the important complications of diabetes. Diabetes is a risk factor for hospitalisation with infection. This study investigated the relationship between LJM of the hand and the incidence of hospitalisation with infection in type 2 diabetic patients. Materials and methods: LJM of hand was defined as the 'prayer sign' or 'table test'. The association between LJM of the hand and incident hospitalisations was evaluated using Cox regression analysis. The number of incident hospitalisations was small over the course of the study, which we compensated for by calculating propensity scores using age, body mass index, sex, duration of diabetes, creatinine, smoking status, haemoglobin A1c and dyslipidaemia. Results: In this retrospective cohort study of 502 patients with type 2 diabetes, 102 patients had LJM of the hand. These patients were, on average, older and had worse renal function and glycaemic control, and a higher proportion of microangiopathy significantly. During the study period, 56 patients were hospitalised with infection. A Cox regression analysis showed that LJM of the hand was associated with an increased probability of incident hospitalisation with infection after adjustment for covariates (HR = 1.65 [95% CI 1.60–1.70], p < 0.001). Conclusions: Our results reveal that LJM of the hand is associated with incident of hospitalisation with infection. A diagnosis of LJM of the hand might, therefore, be a useful indicator for assessing the risk of hospitalisation with infection in type 2 diabetic patients.