Genomics and precision surgery for head and neck squamous cell carcinoma. (1st July 2020)

• Record Type: Journal Article
• Authors: Galmiche, Antoine; Saidak, Zuzana; Bouaoud, Jebrane; Mirghani, Haitham; Page, Cyril; Dakpé, Stéphanie; Clatot, Florian
• Is Part Of: Cancer letters. Volume 481(2020)
• Page Start: 45
• Page End: 54
• Publication Date: 2020-07-01
• Subjects: HNSCC -- Precision surgery -- Genomics -- Surgical margins -- Post-surgical recurrence -- Circulating DNA; circRNA Circular RNA -- ctDNA Circulating tumor DNA -- DOI Depth of Invasion -- END elective neck dissection -- HNSCC Head and neck squamous cell carcinoma -- HPV Human papilloma virus -- ICB immune-checkpoint blockade -- ITH intratumor heterogeneity -- lncRNA Long non coding RNA -- miRNA microRNA -- PNI perineural invasion -- SNB Sentinel node biopsy -- SM Surgical margins -- TCGA The Cancer Genome Atlas -- TME Tumor microenvironment -- TOS Trans Oral Surgery; Cancer -- Periodicals; Neoplasms -- Periodicals; Cancer -- Périodiques; Electronic journals; 616.994
• DOI: 10.1016/j.canlet.2020.04.004
• Languages: English
• ISSNs: 0304-3835

Abstract

Abstract: The identification of the biological determinants that shape the response of tumors to medical therapies offers perspectives for better patient stratification and therapeutic targeting. Here, we discuss how genomics could help to improve the surgical treatment of head and neck squamous cell carcinoma (HNSCC). We examine the potential use of genomic analyses for: i) refining and standardizing the indications for surgery, ii) the choice of surgical procedure, and iii) the follow-up of patients with resected tumors. We highlight the studies that used genomics to explore the contribution of tumor biology to the outcome of surgery. We discuss the important developments that are challenging current surgical practice in HNSCC, such as neoadjuvant immunotherapy and the analysis of circulating DNA. Genomic analyses provide practical tools that could help improve the pathological diagnosis and staging of HNSCC, and increase the appreciation of the importance of tumor biology in the outcome of surgery. Identification of biomarkers will likely contribute to a move toward precision surgery of HNSCC, i.e. the personalization of surgical practice based on tumor biology. Highlights: Tumor biology is rising as an important determinant of the outcome of surgery for HNSCC. Genomics permits integrative studies addressing almost every facet of HNSCC tumor biology. Genomic analyses may be useful for refining and standardizing the indications, the conduct and the follow up of surgery. Genomic biomarkers might contribute to the emergence of precision surgery of HNSCC.