How to determine kidney function in cancer patients?. (June 2020)

• Record Type: Journal Article
• Authors: Sprangers, Ben; Abudayyeh, Ala; Latcha, Sheron; Perazella, Mark A.; Jhaveri, Kenar D.
• Is Part Of: European journal of cancer. Volume 132(2020)
• Page Start: 141
• Page End: 149
• Publication Date: 2020-06
• Subjects: Kidney function -- Glomerular filtration -- GFR formula -- BSA indexing; Cancer -- Periodicals; Neoplasms -- Periodicals; Cancer -- Périodiques; Cancer; Tumors; Electronic journals; Periodicals; Electronic journals; 616.994
• DOI: 10.1016/j.ejca.2020.03.026
• Languages: English
• ISSNs: 0959-8049

Abstract

Abstract: A precise and efficient method for estimating kidney function in cancer patients is important to determine their eligibility for clinical trials and surgery and to allow for appropriate dose adjustment of anti-cancer drugs, especially toxic drugs with a narrow therapeutic index. Since direct measurement of glomerular filtration rate (GFR) is cumbersome, several formulae have been developed to estimate kidney function. Most of these are based on serum creatinine concentration. Though the CKD-EPI formula is recognised as being the most accurate, there is an ongoing debate on which is the optimal formula for cancer patients. In this review, we provide an overview of different GFR estimating equations for kidney function and the advantages and disadvantages of each method and compare their performance in cancer patients. We discuss the importance of body surface area-indexing and propose a framework for evaluating kidney function in cancer patients. Highlights: Estimation of kidney function is essential to provide optimal care for cancer patients. Serum creatinine is an imprecise estimate of kidney function. Creatinine-based formulae have been developed but validation in cancer patients is limited.