Influence of lung transplantation on the essential fatty acid profile in cystic fibrosis. (July 2020)

• Record Type: Journal Article
• Authors: Hanssens, Laurence; Duchateau, J.; Namane, S.A.; Malfroot, A.; Knoop, C.; Casimir, G.
• Is Part Of: Prostaglandins, leukotrienes, and essential fatty acids. Volume 158(2020)
• Publication Date: 2020-07
• Subjects: Cystic fibrosis -- Essential fatty acid -- Polyunsaturated fatty acids -- Lung transplantation; Lipids -- Periodicals; Unsaturated fatty acids -- Periodicals; Prostaglandins -- Periodicals; Leukotrienes -- Periodicals; Fatty Acids, Unsaturated -- Periodicals; Acides gras insaturés -- Périodiques; Prostaglandines -- Périodiques; Leucotriènes -- Périodiques; Lipides -- Périodiques; 612.01577
• DOI: 10.1016/j.plefa.2020.102060
• Languages: English
• ISSNs: 0952-3278

Abstract

Highlights: Essential fatty acid deficiency has been reported to occur in CF patients. Only one work studied the influence of lung transplantation on plasma EFA profile in patients with CF. What are the new findings and/or what is the impact on clinical practice? Compared to the CF group, the plasma levels of total n-3, eicosapentaenoic and docosahexaenoic acids were higher and n-6/n-3 ratio was lower in patients with lung transplantation but these differences were not observed in erythrocyte membrane. The mechanisms leading to the abnormal PUFA profiles in CF remain elusive but abnormal fatty acid metabolism seems probably to be the main factor. Abstract: Lung transplantation is assumed to normalize essential fatty acid (EFA) profile in the plasma, described as abnormal in patients with cystic fibrosis (CF). This study sought to evaluate the EFA profile in both the plasma and erythrocyte membrane according to lung status by comparing CF patients with or without a lung transplant. A total of 50 homozygous F508del patients (33 CF patients [CF group] and 17 CF patients with a lung transplant [TX CF group]) were included. In comparison with the CF group, in the plasma, the levels of total n-3, α-linolenic, eicosapentaenoic, and docosahexaenoic acids were higher and the n-6/n-3 ratio was lower in the TX CF group. Yet, these differences were not observed in the erythrocyte membrane. This study supports that lung transplantation improves the EFA profile in the plasma but not in the erythrocyte membrane by means of the different mechanisms suggested in this article.