Lung cancer survival in never-smokers and exposure to residential radon: Results of the LCRINS study. (1st September 2020) - Casal-Mouriño, Ana
Abstract: We aimed to evaluate lung cancer survival in never-smokers, both overall and specifically by sex, exposure to residential-radon, age, histological type, and diagnostic stage. We included lung cancer cases diagnosed in a multicentre, hospital-based, case-control-study of never-smoker patients, diagnosed from January-2011 to March-2015 (L ung C ancer R esearch I n N ever S mokers study). 369 never-smokers (79% women; median age 71 years; 80% adenocarcinoma; 66% stage IV) were included. Median overall survival, and at one, 3 and 5 years of diagnosis was 18.3 months, 61%, 32% and 22%, respectively. Higher median survival rates were obtained for: younger age, adenocarcinoma, actionable mutations, and earlier-stage at diagnosis. Higher indoor radon showed a higher risk of death in multivariate analysis. Median lung cancer survival in never-smokers seems higher than that in ever-smokers. Patients with actionable mutations have a significantly higher survival. Higher indoor-radon exposure has a negative effect on survival. Highlights: Lung cancer never-smoker patients appear to have a longer median survival than do ever-smokers. Median survival in never-smokers was higher with lower age at diagnosis, adenocarcinoma, presence of mutations and earlier stage. No differences were found for median survival among never-smokers by residential radon concentration.