Colonic Neurogenic Lesion: An Admixture of Mucosal Neurofibromatous Lesion and Submucosal Ganglioneuromatous Lesion With Transition. (August 2020)

• Record Type: Journal Article
• Authors: Hashimoto, Hirotsugu; Koda, Hirotomo; Horiuchi, Hajime; Takayama, Maho; Toyoda, Junya; Momiyama, Masashi; Harihara, Yasushi; Morikawa, Teppei
• Is Part Of: International journal of surgical pathology. Volume 28:Number 5(2020)
• Page Start: 563
• Page End: 568
• Publication Date: 2020-08
• Subjects: neurogenic lesion -- colon -- gastrointestinal tract -- nerve -- ganglioneuroma -- neurofibroma -- transition -- histology -- immunohistochemistry; Pathology, Surgical -- Periodicals; 617.07
• DOI: 10.1177/1066896920904158
• Languages: English
• ISSNs: 1066-8969

Abstract

Benign neural tumors or tumor-like lesions are rarely detected in the gastrointestinal tract. In this article, we present the case of a neural lesion of the sigmoid colon, which was incidentally detected in a 68-year-old man treated with laparoscopic low anterior resection for an advanced carcinoma of the rectosigmoid junction. Within the resected specimen, a submucosal tumor-like protruding lesion was found in the sigmoid colon. Histologically, the growth was composed of mucosal neurofibromatous and submucosal ganglioneuromatous lesions, between which there was transition. Immunohistochemical analysis revealed a rupture of the perineurium in the area of transition, along with a proliferation of Schwann cells and supporting cells extending into the deep mucosa. This transition indicated that the mucosal and submucosal lesions comprised a single lesion, and that a diagnosis of neurofibroma or ganglioneuroma would be inadequate in this case. Because we could not classify it as an established single entity, we diagnosed the mass as an unclassifiable colonic neurogenic lesion. In summary, we report the case of an extremely rare occurrence of an unclassifiable colonic neurogenic lesion comprising an admixture of transitioning mucosal neurofibromatous and submucosal ganglioneuromatous lesions.