Preparation of HAp whiskers with or without Mg ions and their effects on the mechanical properties and osteogenic activity of poly(d, l-lactide). (1st September 2020)

• Record Type: Journal Article
• Authors: Li, Wenyan; Lu, Yaoting; Liu, Kun; Wen, Wei; Liu, Mingxian; Li, Hong; Zhou, Changren; Luo, Binghong
• Is Part Of: Composites. Number 196(2020)
• Publication Date: 2020-09-01
• Subjects: poly(d, l-lactide)-based composites -- Hydroxyapatite whiskers -- Magnesium -- Mechanical property -- Osteogenic activity; Composite materials -- Periodicals; Materials science -- Periodicals; Composite materials; Periodicals; Electronic journals; 620.118
• DOI: 10.1016/j.compositesb.2020.108137
• Languages: English
• ISSNs: 1359-8368

Abstract

Abstract: Hydroxyapatite whiskers (HAp-Ws) and magnesium-substituted hydroxyapatite whiskers (Mg-HAp-Ws) with 1, 3, and 5 mol% magnesium (Mg) ion substitution contents were successfully prepared by the hydrothermal method. The incorporation of Mg ion into the HAp-Ws led to a morphology including a combination of whiskers and particles and a decrease in the crystal interplanar spacing. Then, the HAp-Ws and Mg-HAp-Ws were further introduced into a poly( d, l -lactide) (PDLLA) matrix to prepare HAp-Ws/PDLLA and Mg-HAp-Ws/PDLLA composite films. The existence of HAp-Ws or Mg-HAp-Ws can endow composite films with superior hydrophilicity and tensile properties. Moreover, since the HAp-Ws have a good morphology and a large aspect ratio, the tensile strength and modulus of the HAp-Ws/PDLLA composite film were reasonably higher than those of the Mg-HAp-Ws/PDLLA composite film. The Mg-HAp-Ws/PDLLA composite films were more beneficial for MC3T3-E1 cell adhesion, proliferation and differentiation due to the presence of Mg ions. More importantly, the osteogenic effect of Mg ions on MC3T3-E1 cells is dose-dependent, and the Mg-HAp-Ws/PDLLA composite films with 1–3 mol% Mg ion contents in the Mg-HAp-Ws showed relatively good cytocompatibility and osteogenic activity. In short, the mechanical properties and osteogenic activity of Mg-HAp-Ws/PDLLA composite films can be regulated by adjusting the Mg/Ca content to better meet the needs of bone repair. Highlights: The HAp whiskers with or without Mg ions were prepared via hydrothermal method. The HAp-Ws are more conducive to improving the mechanical property of PDLLA matrix. The Mg-HAp-Ws are better for MC3T3-E1 cells adhesion, growth and differentiation. The osteogenic effect of Mg ions on MC3T3-E1 cells plays in a dose-dependent manner.