Abnormal patterns of corticomuscular and intermuscular coherence in childhood dystonia. Issue 4 (April 2020)

• Record Type: Journal Article
• Authors: McClelland, Verity M.; Cvetkovic, Zoran; Lin, Jean-Pierre; Mills, Kerry R.; Brown, Peter
• Is Part Of: Clinical neurophysiology. Volume 131:Issue 4(2020:Apr.)
• Page Start: 967
• Page End: 977
• Publication Date: 2020-04
• Subjects: Dystonia -- Children -- Sensorimotor integration -- Corticomuscular coherence -- Intermuscular coherence; CMC corticomuscular coherence -- EEG electroencephalogram -- EMG electromyogram -- IMC intermuscular coherence -- FDI First Dorsal Interosseous -- FExt Forearm Extensors -- DBS Deep Brain Stimulation -- BFMDRS-m Burke-Fahn-Marsden Dystonia Rating Scale motor score -- MVC maximum voluntary contraction -- IQR inter-quartile range -- ERD Event Related Desynchronisation -- ERS Event Related Synchronisation -- CV Coefficient of Variation; Neurophysiology -- Periodicals; Electroencephalography -- Periodicals; Electromyography -- Periodicals; Neurology -- Periodicals; 612.8
• DOI: 10.1016/j.clinph.2020.01.012
• Languages: English
• ISSNs: 1388-2457

Abstract

Highlights: Beta-corticomuscular coherence and its modulation by peripheral stimulation is abnormal in dystonia. Modulation of beta-corticomuscular coherence differs between idiopathic/genetic & acquired dystonia. Strong 4–12 Hz intermuscular coherence is common to idiopathic/genetic & acquired dystonia. Abstract: Objective: Sensorimotor processing is abnormal in Idiopathic/Genetic dystonias, but poorly studied in Acquired dystonias. Beta-Corticomuscular coherence (CMC) quantifies coupling between oscillatory electroencephalogram (EEG) and electromyogram (EMG) activity and is modulated by sensory stimuli. We test the hypothesis that sensory modulation of CMC and intermuscular coherence (IMC) is abnormal in Idiopathic/Genetic and Acquired dystonias. Methods: Participants: 11 children with Acquired dystonia, 5 with Idiopathic/Genetic dystonia, 13 controls (12–18 years). CMC and IMC were recorded during a grasp task, with mechanical perturbations provided by an electromechanical tapper. Coherence patterns pre- and post-stimulus were compared across groups. Results: Beta-CMC increased post-stimulus in Controls and Acquired dystonia (p = 0.001 and p = 0.010, respectively), but not in Idiopathic/Genetic dystonia (p = 0.799). The modulation differed between groups, being larger in both Controls and Acquired dystonia compared with Idiopathic/Genetic dystonia (p = 0.003 and p = 0.022). Beta-IMC increased significantly post-stimulus in Controls (p = 0.004), but not in dystonia. Prominent 4–12 Hz IMC was seen in all dystonia patients and correlated with severity (rho = 0.618). Conclusion: Idiopathic/Genetic and Acquired dystonia share an abnormal low-frequency IMC. In contrast, sensory modulation of beta-CMC differed between the two groups. Significance: The findings suggest that sensorimotor processing is abnormal in Acquired as well as Idiopathic/Genetic dystonia, but that the nature of the abnormality differs.