Degradation of methoxy-poly (ethylene glycol)-block-poly(α-carboxyl-ε-caprolactone)/magnetite nanocomposites in vitro polymer degradation and stability. (July 2020)

• Record Type: Journal Article
• Authors: Li, Yang; Liu, Yu; Zhu, Hongyu; Shuai, Shirong; Zhao, Cong; Zhou, Kanghong; Ge, Wei; Hao, Jianyuan
• Is Part Of: Polymer degradation and stability. Volume 177(2020)
• Publication Date: 2020-07
• Subjects: Carboxyl groups -- Magnetic nanoparticles -- Nanocomposites degradation; Polymers -- Deterioration -- Periodicals; Stabilizing agents -- Periodicals; Polymères -- Dégradation -- Périodiques; Stabilisants -- Périodiques; 668.9
• DOI: 10.1016/j.polymdegradstab.2020.109191
• Languages: English
• ISSNs: 0141-3910

Abstract

Abstract: Methoxy-poly (ethylene glycol)-block-poly (α-carboxyl-ε-caprolactone)/Fe3 O4 nanocomposites (mPEG-b-PCCL@Fe3 O4 ) with spherical shape, more negative and smoother surface and core-sell structure were prepared by simply changing the solvent. Their degradation behavior was systematically investigated at 37 °C in distilled water and buffers with different pH values. The mPEG-b-PCCL micelles were used as the contrast. Although the acid inhibition and basic promoting degradation were observed for both mPEG-b-PCCL@Fe3 O4 and micelles, the existence of magnetite nanoparticles (MNPs) and more surface –COOH slowed down the degradation of nanocomposites due to the dissociation hindrance of –COOH, the hydrophobicity and the cross-linking effects of MNPs. The degradation of mPEG-b-PCCL@Fe3 O4 underwent the surface degradation at initial time and bulk degradation after complete swelling of the hydrophobic core. These investigations suggested that the degradation of mPEG-b-PCCL@Fe3 O4 was more designable and controllable than that of micelles. Highlights: Simply changing the solvent, mPEG-b-PCCL@Fe3 O4 nanocomposites with spherical shape, more negative and smoother surface, and distinct core-shell structure were prepared. The degradation of mPEG-b-PCCL@Fe3 O4 nanocomposites underwent the surface degradation at initial time and bulk degradation after complete swelling. Fe3 O4 nanoparticles slowed down the degradation of nanocomposites through hydrophobic property, cross-linking effects.