Metabolomics reveals plausible interactive effects between dairy product consumption and metabolic syndrome in humans. Issue 5 (May 2020)

• Record Type: Journal Article
• Authors: Capel, Frédéric; Bongard, Vanina; Malpuech-Brugère, Corinne; Karoly, Edward; Michelotti, Gregory A.; Rigaudière, Jean Paul; Jouve, Chrystèle; Ferrières, Jean; Marmonier, Corinne; Sébédio, Jean Louis
• Is Part Of: Clinical nutrition. Volume 39:Issue 5(2020)
• Page Start: 1497
• Page End: 1509
• Publication Date: 2020-05
• Subjects: Metabolic syndrome -- Dairy products -- Untargeted metabolomics -- Lipidomic -- Clinical parameters -- Humans; Critically ill -- Nutrition -- Periodicals; Diet therapy -- Periodicals; Parenteral feeding -- Periodicals; Enteral feeding -- Periodicals; Enteral Nutrition -- Periodicals; Parenteral Nutrition -- Periodicals; Metabolism -- Periodicals; Diétothérapie -- Périodiques; Alimentation parentérale -- Périodiques; Alimentation entérale -- Périodiques; Nutrition -- Périodiques; Diet therapy; Enteral feeding; Nutrition; Parenteral feeding; Electronic journals; Periodicals; Electronic journals; 615.854
• DOI: 10.1016/j.clnu.2019.06.013
• Languages: English
• ISSNs: 0261-5614

Abstract

Summary: Background & aims: Metabolic syndrome (MetS) induces major disturbances in plasma metabolome, reflecting abnormalities of several metabolic pathways. Recent evidences have demonstrated that the consumption of dairy products may protect from MetS, but the mechanisms remains unknown. The present study aimed at identify how the consumption of different types of dairy products could modify the changes in plasma metabolome during MetS. Methods: In this observational study, we analyzed how the consumption of dairy products could modify the perturbations in the plasma metabolome induced by MetS in a sample of 298 participants (61 with MetS) from the French MONA LISA survey. Metabolomic profiling was analyzed with UPLC-MS/MS. Results: Subjects with MetS exhibited major changes in plasma metabolome. Significant differences in plasma levels of branched chain amino acids, gamma-glutamyl amino acids, and metabolites from arginine and proline metabolism were observed between healthy control and Mets subjects. Plasma levels of many lipid species were increased with MetS (mono- and diacylglycerols, eicosanoids, lysophospholipids and lysoplasmalogens), with corresponding decreases in short chain fatty acids and plasmalogens. The consumption of dairy products, notably with a low fat content (milk and fresh dairy products), altered metabolite profiles in plasma from MetS subjects. Specifically, increasing consumption of dairy products promoted accumulation of plasma C15:0 fatty acid and was inversely associated to some circulating lysophospholipids, sphingolipids, gamma-glutamyl amino acids, leukotriene B4 and lysoplasmalogens. Conclusions: the consumption of low fat dairy products could mitigate some of the variations induced by MetS.