Diagnosing cardiac amyloidosis in every-day practice: A practical guide for the cardiologist. (June 2020)

• Record Type: Journal Article
• Authors: Papathanasiou, Maria; Carpinteiro, Alexander; Rischpler, Christoph; Hagenacker, Tim; Rassaf, Tienush; Luedike, Peter
• Is Part Of: IJC heart & vasculature. Volume 28(2020)
• Publication Date: 2020-06
• Subjects: Amyloidosis -- Cardiomyopathy -- Heart failure -- Transthyretin -- Light chains; AA amyloid A amyloidosis -- AApoA-1 apolipoprotein A-1 amyloidosis -- AL light chain amyloidosis -- ATTR transthyretin amyloidosis -- ATTRv variant transthyretin amyloidosis -- ATTRwt wild type transthyretin amyloidosis -- CA cardiac amyloidosis -- ECV Extracellular volume -- EMB endomyocardial biopsy -- LGE late gadolinium enhancement -- LV left ventricular/ left ventricular -- MGUS monoclonal gammopathy of undetermined significance -- MRI magnetic resonance imaging -- NT-proBNP N-terminal pro B-type natriuretic peptide -- PET positron-emission tomography -- SPECT single photon emission computed tomography -- 99mTc-DPD 99mTc-3, 3-diphosphono-1, 2-propanodicarboxylic acid; Cardiovascular system -- Diseases -- Periodicals; Cardiovascular system -- Pathophysiology -- Periodicals; 616.1005
• DOI: 10.1016/j.ijcha.2020.100519
• Languages: English
• ISSNs: 2352-9067

Abstract

Abstract: Cardiac amyloidosis (CA) has emerged as a previously underestimated cause of heart failure and mortality. Underdiagnosis resulted mainly from unawareness of the true disease prevalence and the non-specific symptoms of the disease. CA results from extracellular deposition of misfolded protein fibrils, commonly derived from transthyretin (ATTR) or immunoglobulin light chains (AL). A significant proportion of older patients with heart failure and other extracardiac manifestations suffer from ATTR-CA, whereas AL-CA is still considered a rare disease. This article provides an overview of CA with a special focus on current and emerging diagnostic modalities. Furthermore, we provide a diagnostic algorithm for the evaluation of patients with suspected CA in every-day practice.