Glucitol-core containing gallotannins-enriched red maple (Acer rubrum) leaves extract alleviated obesity via modulating short-chain fatty acid production in high-fat diet-fed mice. (July 2020)

• Record Type: Journal Article
• Authors: Li, Liya; Ma, Hang; Liu, Tingting; Ding, Zhanjun; Liu, Wei; Gu, Qiong; Mu, Yu; Xu, Jun; Seeram, Navindra P.; Huang, Xueshi; Xu, Jialin
• Is Part Of: Journal of functional foods. Volume 70(2020)
• Publication Date: 2020-07
• Subjects: Obesity -- Red maple -- Gallotannin -- Gut microbiota -- SCFA -- Adipogenesis; Acc acetyl-CoA carboxylase -- AUC area under curve -- Cebpα CCAAT enhancer binding protein alpha -- CD36 cluster of differentiation 36 -- Chol cholesterol -- Cyp7a1 cholesterol 7α-hydroxylase -- ETs ellagitannins -- FFA free fatty acid -- GAPDH glyceraldehyde-3-phosphate dehydrogenase -- GCGs 1, 5-anhydro-glucitol core containing gallotannins -- GTs gallotannins -- GTT glucose tolerance test -- HFD high-fat diet -- HMG-CoA Red HMG-CoA reductase -- HMG-CoA Syn HMG-CoA synthase -- HTs hydrolyzable tannins -- Il-6 interleukin-6 -- ITT insulin tolerance test -- Ldlr low-density lipoprotein receptor -- LEfSe linear discriminant analysis effect size -- Mcp1 monocyte chemoattractant protein 1 -- Mip1α macrophage inflammatory protein 1α -- MLE red maple leaves extract -- NF-κB nuclear factor kappa B -- OTUs operational taxonomic units -- Pparγ peroxisome proliferator-activated receptor gamma -- PYY peptide YY -- SCFAs short-chain fatty acids -- SD standard diet -- Srebp1c sterol regulatory element-binding protein 1c -- TG triglycerides -- TNFα tumor necrosis factor alpha -- UPGMA unweight pair group method with arithmetic mean -- WAT white adipose tissue; Functional foods -- Analysis -- Periodicals; Food -- Biotechnology -- Periodicals; Nutrition -- Periodicals; 613.2
• DOI: 10.1016/j.jff.2020.103970
• Languages: English
• ISSNs: 1756-4646

Abstract

Graphical abstract: Highlights: MLE alleviated diet-induced obesity without impacting energy intake. MLE ameliorated liver steatosis and local low-grade inflammation in HFD-fed mice. MLE increased colon-derived total SCFAs and n -butyric acid production. The anti-obesity effects of MLE are partially due to the modulation of gut flora. Abstract: Glucitol-core containing gallotannins (GCGs) are characteristic constituents of the red maple ( Acer rubrum ) species. To pursue the development of red maple for nutraceutical applications, GCGs-enriched red maple leaves extract (MLE) was evaluated for its effects on obesity, gut dysbiosis and short chain fatty acids (SCFAs) production. Our results demonstrated that MLE alleviated high-fat diet-induced obesity, reduced body weight gain and fat mass, improved liver steatosis and insulin resistance, and mitigated adipose hypertrophy and inflammation. Additionally, MLE increased total SCFAs, acetic acid and n -butyric acid content, but exerted no impact on propionic acid production. Moreover, MLE modulated gut microbiota community structure and certain bacteria relative abundance, including Prevotella and Eubacterium . Our work firstly reports a potential association between colon-derived SCFAs production and metabolic improvement due to GCGs-enriched red maple leaves extract administration, and highlights the utilization of red maple gallotannins as a dietary ingredient for preventing obesity and related metabolic diseases.