1, 2, 3-Triazole β-lactam conjugates as antimicrobial agents. Issue 6 (June 2020)

• Record Type: Journal Article
• Authors: Kaur, Rajneesh; Singh, Raman; Kumar, Antresh; Kaur, Satvinder; Priyadarshi, Nitesh; Singhal, Nitin Kumar; Singh, Kuldeep
• Is Part Of: Heliyon. Volume 6:Issue 6(2020)
• Publication Date: 2020-06
• Subjects: Pharmaceutical chemistry -- Microbiology -- Triazole -- Beta-lactam -- Conjugates -- Antibacterial assay; Research -- Periodicals; Medical sciences -- Periodicals; Natural history -- Periodicals; Social sciences -- Periodicals; Earth sciences -- Periodicals; Physical sciences -- Periodicals; 507.2
• DOI: 10.1016/j.heliyon.2020.e04241
• Languages: English
• ISSNs: 2405-8440

Abstract

Abstract: A convenient and efficient synthesis of new triazole β-lactam conjugates using click chemistry is described. β-lactam 15 and 16 were prepared using cycloaddition strategy and propargylated at N -1 to afford compounds 17 and 18 . Cu-catalyzed click reaction of these β-lactams 17 and 18 with different aryl azides provided 1, 2, 3-triazole conjugates 6 and 7, respectively. The products were fully characterized spectroscopically and tested against Gram-(+) and Gram-(-) bacteria. Compound 7a and 7c were found to be most active. Abstract : Pharmaceutical chemistry; Microbiology, Triazole; Beta-lactam; Conjugates; Antibacterial assay.