Stable aqueous dispersions of carbon nanohorns loaded with minocycline and exhibiting antibacterial activity. (30th September 2020)

• Record Type: Journal Article
• Authors: Maeda, Yukari; Hirata, Eri; Takano, Yuta; Sakaguchi, Norihito; Ushijima, Natsumi; Saeki, Ayumi; Kimura, Sadahito; Shibata, Ken-ichiro; Yudasaka, Masako; Yokoyama, Atsuro
• Is Part Of: Carbon. Volume 166(2020)
• Page Start: 36
• Page End: 45
• Publication Date: 2020-09-30
• Subjects: Carbon -- Periodicals; Carbone -- Périodiques; Koolstof; Toepassingen; Electronic journals; 546.681
• DOI: 10.1016/j.carbon.2020.04.040
• Languages: English
• ISSNs: 0008-6223

Abstract

Abstract: This work demonstrates that certain medically-approved drugs possess dual functions such that they exhibit intrinsic drug effects and can assist in dispersing carbon nanomaterials. Two types of carbon nanohorns (CNHs) (unoxidized: as-CNH, oxidized: CNHox550) and carbon nanotubes (CNTs) were successfully dispersed in aqueous solutions using minocycline (MC) as a dispersant. Absorption spectra, thermogravimetric analyses and theoretical calculations demonstrated that the MC was attached to the CNHs in these dispersions. The antibacterial activities of these MC/CNH complexes were examined using Streptcoccus mutans and Aggregatibacter actinomycetemcomitans, and the MC/as-CNH complex was found to maintain the same bacterial growth inhibition activity as the original MC. Electron microscopy observations suggested direct contact of the MC/CNH complexes with the bacteria, presumably allowing delivery of the MC. The results obtained from our study demonstrate that drug/nanocarbon complexes have potential applications in drug delivery. Graphical abstract: Image 1