Laboratory and clinical findings and their association with viral and proviral loads in cats naturally infected with feline leukemia virus. (August 2020)

• Record Type: Journal Article
• Authors: Duda, Naila C.B.; Ortiz, Lucía Cano; Valle, Stella Faria; da Costa, Fernanda V.A.; Varela, Ana Paula Muterle; Nunes, Nilson J.S.; Okano, Felipe Yuji; Franco, Ana Cláudia; Roehe, Paulo Michel; González, Félix H.D.
• Is Part Of: Comparative immunology, microbiology and infectious diseases. Volume 71(2020)
• Publication Date: 2020-08
• Subjects: ALL acute lymphocytic leukemia -- ALP alkaline phosphatase -- AML acute myeloid leukemia -- AML-M6 erythroleukemia -- BM bone marrow -- CBC complete blood count -- ELISA enzyme-linked immunosorbent assay -- FeLV feline leukemia virus -- FIV feline immunodeficiency virus -- Hb hemoglobin -- Ht hematocrit -- IgG immunoglobulin G -- IgM immunoglobulin M -- IMHA immune-mediated hemolytic anemia -- LTR long terminal repeat -- MCHC mean corpuscular hemoglobin concentration -- MDS myelodysplastic syndrome -- MDS-Er myelodysplastic syndrome with erythroid predominance -- MCV mean corpuscular volume -- M:E myeloid to erythroid ratio -- PCR polymerase chain reaction -- qPCR quantitative real-time PCR -- RBC red blood cell -- WBC white blood cell; Feline retrovirus -- Laboratory abnormalities -- Hematopoietic disorders -- Bone marrow -- Virus quantification; Communicable diseases in animals -- Periodicals; Veterinary immunology -- Periodicals; Veterinary microbiology -- Periodicals; Immunology -- Periodicals; Microbiology -- Periodicals; Communicable diseases -- Periodicals; Communicable Diseases -- immunology -- Periodicals; Communicable Diseases -- veterinary -- Periodicals; Allergy and Immunology -- Periodicals; Microbiology -- Periodicals; Veterinary Medicine -- Periodicals; Immunologie -- Périodiques; Microbiologie -- Périodiques; Maladies infectieuses -- Périodiques; Communicable diseases; Immunology; Microbiology; Electronic journals; Periodicals; 636.08969
• DOI: 10.1016/j.cimid.2020.101491
• Languages: English
• ISSNs: 0147-9571

Abstract

Highlights: Myelodisplastic disorders are associated with higher bone marrow proviral loads. Viral and proviral loads in serum or bone marrow classify the infection stage. Molecular methods to detect feline leukemia virus for endemic areas. Severity of hematological disease depends of leukemia viral and proviral loads. Abstract: This study was conducted to correlate clinical, laboratory, and bone marrow (BM) changes in cats naturally infected with feline leukemia virus and their association with viral loads in blood and BM and proviral loads in BM. Cats were classified into five groups based on antigenemia, clinical and/or laboratory findings and viral/proviral loads, according to a prospective study: symptomatic progressive (GI); asymptomatic progressive (GII); regressive (GIII); unclassified (GIV); or healthy (GV). |Correlations between these five groups and viral/proviral loads were evaluated. High viral and proviral loads were detected in GI and GII and viral loads were significantly associated with laboratory signs. Proviral loads detected in BM were significantly lower in GIII and GIV. GI cats were more likely to develop hematopoietic disorders than those from the other groups. Hematological and clinical disorders and disease severity are related to higher viral blood and proviral BM loads.