Antioxidant properties of plant polyphenols in the counteraction of alcohol-abuse induced damage: Impact on the Mediterranean diet. (August 2020)

• Record Type: Journal Article
• Authors: Fiore, Marco; Messina, Marisa Patrizia; Petrella, Carla; D'Angelo, Alessio; Greco, Antonio; Ralli, Massimo; Ferraguti, Giampiero; Tarani, Luigi; Vitali, Mario; Ceccanti, Mauro
• Is Part Of: Journal of functional foods. Volume 71(2020)
• Publication Date: 2020-08
• Subjects: Polyphenols -- Neurotrophins -- Mediterranean diet -- Alcohol -- Fetal alcohol spectrum disorders -- Oxidative stress; Functional foods -- Analysis -- Periodicals; Food -- Biotechnology -- Periodicals; Nutrition -- Periodicals; 613.2
• DOI: 10.1016/j.jff.2020.104012
• Languages: English
• ISSNs: 1756-4646

Abstract

Graphical abstract: Highlights: Polyphenols taken in the Mediterranean diet have strong antioxidant properties. Alcohol can cause relevant oxidative stress and disrupt neurotrophins metabolism. Polyphenols in red wine and extra-virgin olive oil can counterbalance alcohol-induced damage. Abstract: Polyphenols are antioxidants contained in plants as olive and grape. As part of the Mediterranean diet, they may decrease the risk of cancer, of chronic and neurodegenerative diseases. Alcohol consumption plays a detrimental effect on health, causing tissue damage and disrupting the metabolism of Neurotrophins (NTs). NTs are crucial proteins for the life cycle of neuronal and non-neuronal cells. Alcohol abuse elicits changes in NTs levels in the brain and in other target organs, however, it was observed minor damage in animals early exposed to red wine, probably due to the antioxidant effects of polyphenols. Indeed, data show that resveratrol or other polyphenols extracted from the olive can effectively counteract serum free radicals' formation caused by chronic alcohol intake, contrasting also alcohol-induced NTs liver elevation. The aim of the present review is to update pieces of evidences about the antioxidant properties of polyphenols and their role in counteracting alcohol-induced damage.