Maresin-1 resolution with RORα and LGR6. (April 2020)

• Record Type: Journal Article
• Authors: Im, Dong-Soon
• Is Part Of: Progress in lipid research. Volume 78(2020)
• Publication Date: 2020-04
• Subjects: Maresin-1 -- Nuclear receptor -- G protein-coupled receptor -- Inflammation -- Resolution -- LGR6 -- RORα; Lipids -- Periodicals; Lipids -- Periodicals; Lipides -- Périodiques; Lipiden; 572.57
• DOI: 10.1016/j.plipres.2020.101034
• Languages: English
• ISSNs: 0163-7827

Abstract

Abstract: Maresin-1, a pro-resolving lipid mediator, is drawing a great deal of attention in receptor pharmacology, largely because two distinct types of receptor molecules have been reported as the targets of maresin-1. One is retinoic acid-related orphan receptor α (RORα) and the other is leucine-rich repeat domain-containing G protein-coupled receptor 6 (LGR6). RORα is a nuclear receptor and LGR6 is a plasma membrane GPCR. Identification of two different molecular targets raises the following question: What are the pro-resolving functions of each receptor in inflammation resolution, host defense, tissue homeostasis, and wound healing? In this article, I review the new targets from the point of view of pharmacology and maresin-1 resolution along with intracellular signaling molecules.