Distant myonecrosis by atraumatic Clostridium septicum infection in a patient with metastatic breast cancer. (2020)

• Record Type: Journal Article
• Authors: Gray, Kelsey M.; Padilla, Pablo L.; Sparks, Blake; Dziewulski, Peter
• Is Part Of: IDCases. Volume 20(2020)
• Publication Date: 2020
• Subjects: Clostridium septicum -- Atraumatic myonecrosis -- Breast cancer; Communicable diseases -- Periodicals; Communicable Diseases -- Case Reports; Communicable Diseases -- Periodicals; Communicable diseases; Periodicals; 616.9
• DOI: 10.1016/j.idcr.2020.e00784
• Languages: English
• ISSNs: 2214-2509

Abstract

Highlights: Atraumatic Clostridium septicum infection is seen in metastatic breast cancer. Rapid identification and aggressive treatment atypical of clostridial species is required. Atraumatic infection may require debridement beyond visible necrosis. Abstract: Clostridium septicum is an anaerobic, gram-positive bacillus known to cause myonecrosis, also known as gas gangrene, a life-threatening necrotizing soft tissue infection. Though it accounts for just 1 % of all infections attributable to Clostridia spp., C. septicum is a highly virulent and aggressive pathogen. Classic presentations of infection include bacteremia resulting in shock, myonecrosis, and vascular seeding. C. septicum- associated gas gangrene most commonly occurs in the setting of traumatic injury, but has also been reported in patients with colorectal malignancy, immunosuppression, neutropenia, and exceedingly rare in association with breast cancer. We report the case of a 56-year-old female patient with stage IV mixed lobar and ductal breast carcinoma with metastasis to the bone and liver, who presented with spontaneous C. septicum myonecrosis of the right hand. No prior traumatic injury was noted. Following amputation of the right forearm, antibiotic treatment, and multiorgan support, the patient passed following transition to palliative care. We hope to increase awareness of this relatively uncommon, though potentially deadly pathogen, as well as to discuss treatment options in patients infected with C. septicum .