The cytokine storm in COVID-19: An overview of the involvement of the chemokine/chemokine-receptor system. (June 2020)

• Record Type: Journal Article
• Authors: Coperchini, Francesca; Chiovato, Luca; Croce, Laura; Magri, Flavia; Rotondi, Mario
• Is Part Of: Cytokine & growth factor reviews. Volume 53(2020)
• Page Start: 25
• Page End: 32
• Publication Date: 2020-06
• Subjects: AP-1 activator protein-1 -- ARDS acute respiratory distress syndrome -- COVID-19 Coronavirus Disease 2019 -- CSF colony-stimulating factors -- DNA deoxyribonucleic acid -- ICU Intensive Care Units -- IFN interferon -- IL- interleukin -- IRF interferon regulatory transcription factor -- LPS lipopolysaccharide -- MERS Middle East Respiratory Syndrome -- MERS-CoV Middle East Respiratory Syndrome Coronavirus -- NF-kB nuclear factor kappa-light-chain-enhancer of activated B cells -- PBMCs Peripheral Blood Mononuclear Cells -- RNA Ribonucleic Acid -- SARS Severe Acute Respiratory Syndrome -- SARS-CoV Severe Acute Respiratory Syndrome Coronavirus -- SARS-CoV-2 severe acute respiratory syndrome coronavirus 2 -- TH1 T-helper-1 -- TNF Tumor Necrosis Factor; COVID-19 -- Coronavirus -- Chemokines -- CXCL10 -- CXCL8 -- Cytokine storm; Cytokines -- Periodicals; 571.84
• DOI: 10.1016/j.cytogfr.2020.05.003
• Languages: English
• ISSNs: 1359-6101

Abstract

Highlights: COVID-19 pandemic is raging worldwide and is putting health-care systems under severe strain. The "cytokine storm" and the subsequent ARDS result from the effects of the combination of several immune-active molecules. The "cytokine storm" is the most dangerous and potentially life-threatening event related to COVID-19. The chemokine system is involved in the pathogenesis of severe clinical sequelae of COVID-19, similarly to SARS and MERS. Abstract: In 2019–2020 a new coronavirus named SARS-CoV-2 was identified as the causative agent of a several acute respiratory infection named COVID-19, which is causing a worldwide pandemic. There are still many unresolved questions regarding the pathogenesis of this disease and especially the reasons underlying the extremely different clinical course, ranging from asymptomatic forms to severe manifestations, including the Acute Respiratory Distress Syndrome (ARDS). SARS-CoV-2 showed phylogenetic similarities to both SARS-CoV and MERS-CoV viruses, and some of the clinical features are shared between COVID-19 and previously identified beta-coronavirus infections. Available evidence indicate that the so called "cytokine storm" an uncontrolled over-production of soluble markers of inflammation which, in turn, sustain an aberrant systemic inflammatory response, is a major responsible for the occurrence of ARDS. Chemokines are low molecular weight proteins with powerful chemoattractant activity which play a role in the immune cell recruitment during inflammation. This review will be aimed at providing an overview of the current knowledge on the involvement of the chemokine/chemokine-receptor system in the cytokine storm related to SARS-CoV-2 infection. Basic and clinical evidences obtained from previous SARS and MERS epidemics and available data from COVID-19 will be taken into account.