A multifuctional nanoplatform for drug targeted delivery based on radiation-engineered nanogels. (April 2020)

• Record Type: Journal Article
• Authors: Sabatino, Maria Antonietta; Ditta, Lorena Anna; Conigliaro, Alice; Dispenza, Clelia
• Is Part Of: Radiation physics and chemistry. Volume 169(2020:Apr.)
• Publication Date: 2020-04
• Subjects: Nanogels -- Drug delivery -- Ionising radiation synthesis -- Nanomedicine -- Conjugation reactions; Radiation chemistry -- Periodicals; Radiometry -- Periodicals; Radiation -- Periodicals; Chimie sous rayonnement -- Périodiques; 539.2
• DOI: 10.1016/j.radphyschem.2018.11.013
• Languages: English
• ISSNs: 0969-806X

Abstract

Abstract: Under a rational design, combining biologically active molecules, ligands to specific cell receptors and fluorescent, radioactive or paramagnetic labels into a single nano-object can bridge the unique properties of the individual components and improve conventional sensing, imaging and therapeutic efficacies. The validation of these functional nano-objects requires careful testing both in terms of physico-chemical properties and biological behaviour in vitro and in vivo, prior to translation into the clinic. Ionising radiation of aqueous polymer solutions is a viable strategy to produce multifunctional nanogels from aqueous solutions of hydrophilic polymers. By proper selection of the irradiation conditions, polymer concentration and gaseous atmosphere, nanogels with the desired features in terms of dimensions, surface electric charge and chemical reactivity can be produced. In particular, radiation-engineered poly(N-vinyl pyrrolidone)-based nanogels bearing carboxyl groups and primary amines can be used as the main building block of promising theranostic nanodevices. The possibility of exploiting these functional groups to bind molecules of interest for their characterisation and biological evaluation is discussed. Highlights: Nanogels are fascinating delivery systems with great potential in the biomedical field. Nanogels with various size and functional groups can be synthetized by e-beam irradiation from the same aqueous polymer. Grafting of acrylic acid to PVP nanogels increases the number of functional groups that are available for conjugation reactions. The covalent attachment of various (bio)molecules of interest on the same nanogel is demonstrated. Nanogel-cell interactions are significantly affected by the conjugation reactions.