Dihydrochalcone C-glycosides from Averrhoa carambola leaves. (June 2020)

• Record Type: Journal Article
• Authors: Yang, Yue; Jia, Xuchao; Xie, Haihui; Wei, Xiaoyi
• Is Part Of: Phytochemistry. Volume 174(2020)
• Publication Date: 2020-06
• Subjects: Averrhoa carambola -- Oxalidaceae -- Star fruit -- Leaf -- Dihydrochalcone C-Glycoside -- Quantitative analysis -- Antioxidant activity -- Pancreatic lipase inhibition; RTIBMFWARWXYEN-DKZLLWCDSA-N; Botanical chemistry -- Periodicals; Biochemistry -- Periodicals; Botany -- Periodicals; Chimie végétale -- Périodiques; 572.2
• DOI: 10.1016/j.phytochem.2020.112364
• Languages: English
• ISSNs: 0031-9422

Abstract

Abstract: Ten undescribed dihydrochalcone C -glycosides, carambolasides R1‒R3, S1, S2, T1‒T3, 3-hydroxycarambolaside T1, and 3-hydroxycarambolaside P were isolated along with carambolasides I and P from the leaves of Averrhoa carambola L. (Oxalidaceae). Their structures were determined by spectroscopic and chemical methods. Among them, carambolasides P, T1, T2, and I with contents of 22.78, 14.39, 4.93, and 1.87 mg g −1 dry wt., respectively, were shown to be abundant in the leaves by HPLC analysis. All the compounds showed more potent ABTS radical cation scavenging activity than l -ascorbic acid. 3-Hydroxycarambolaside T1 and 3-hydroxycarambolaside P also demonstrated moderate DPPH radical scavenging activity. Further, carambolaside R3, 3-hydroxycarambolaside T1, and 3-hydroxycarambolaside P exhibited weak in vitro porcine pancreatic lipase inhibitory activity. Graphical abstract: From Averrhoa carambola leaves, ten undescribed and two known dihydrochalcone C -glycosides were isolated, which showed potent antioxidant and weak pancreatic lipase inhibitory activities. The contents of five compounds were measured. Image 1 Highlights: Ten undescribed dihydrochalcone C -glycosides were isolated from A. carambola leaves. The contents of five compounds were measured. All the compounds showed potent ABTS radical cation scavenging activity. Three compounds exhibited weak pancreatic lipase inhibitory activity.