Pharmacological Targeting of the Actin Cytoskeleton to Drive Endocrinogenesis. (June 2020)

• Record Type: Journal Article
• Authors: Siehler, Johanna; Blöchinger, Anna Karolina; Lickert, Heiko
• Is Part Of: Trends in pharmacological sciences. Volume 41:Number 6(2020)
• Page Start: 384
• Page End: 386
• Publication Date: 2020-06
• Subjects: beta cells -- actin -- stem cells -- Latrunculin A -- pancreatic progenitors -- endocrine progenitors; Pharmacology -- Periodicals; Pharmacology -- trends -- Periodicals; Pharmacologie -- Périodiques; Pharmacology; Electronic journals; Periodicals; 615.1
• DOI: 10.1016/j.tips.2020.04.002
• Languages: English
• ISSNs: 0165-6147

Abstract

Abstract : In vitro generation of insulin-secreting beta cells from human pluripotent stem cells (hPSCs) opens new avenues for treating and modeling diabetes. Hogrebe and colleagues established a new 2D differentiation protocol where they targeted the cytoskeleton pharmacologically for controlled endocrine induction and generation of hPSC-derived beta cells with improved function.