Another case of mistaken identity? Vaccinia virus in another live Camelpox vaccine. (May 2020)

• Record Type: Journal Article
• Authors: Saud, Zack; Butt, Tariq M.
• Is Part Of: Biologicals. Volume 65(2020)
• Page Start: 39
• Page End: 41
• Publication Date: 2020-05
• Subjects: Orthopox -- Vaccinia -- Camelpox -- Sequencing -- Passaging -- Attenuation; Biological products -- Standards -- Periodicals; Biological Products -- Periodicals; Biological Products -- standards -- Periodicals; Produits biologiques -- Normes -- Périodiques; Biological products -- Standards; Periodicals; 615.37
• DOI: 10.1016/j.biologicals.2020.04.002
• Languages: English
• ISSNs: 1045-1056

Abstract

Abstract: Camelpox virus is the causative agent of Camelpox, a highly contagious disease of camels. A high passage Camelpox virus strain has previously been reported to contain several genes which more closely resemble Vaccinia, a virus species with no known natural host, encompassing various strains that show high inter-strain genomic variation. In this study, we demonstrate that yet another high passage, live attenuated vaccine, comprising a different strain of Camelpox virus, contains genomic sequences that match a differing strain of Vaccinia virus. These results are discussed in the context of hypotheses put forward to explain the unknown origins of Vaccinia virus, suggesting further studies to elucidate evolutionary trajectories of Orthopoxviruses through passaging.