A 3D-printable TEMPO-oxidized bacterial cellulose/alginate hydrogel with enhanced stability via nanoclay incorporation. (15th June 2020)

• Record Type: Journal Article
• Authors: Wei, Jiaxin; Wang, Baoxiu; Li, Zhe; Wu, Zhuotong; Zhang, Minghao; Sheng, Nan; Liang, Qianqian; Wang, Huaping; Chen, Shiyan
• Is Part Of: Carbohydrate polymers. Volume 238(2020)
• Publication Date: 2020-06-15
• Subjects: 3D-printable hydrogel -- Bacterial cellulose -- Alginate -- Nanoclay -- Stability; Polysaccharides -- Periodicals; Polysaccharides -- Periodicals; Polysaccharides -- Périodiques; Electronic journals; 547.78
• DOI: 10.1016/j.carbpol.2020.116207
• Languages: English
• ISSNs: 0144-8617

Abstract

Highlights: The nanocomposite printing ink exhibited excellent printability for complexity and high shape fidelity. Nanoclay can effectively improve the stability of the 3D printable hydrogel in PBS. The sustained and prolonged protein delivery of hydrogel were achieved through nanoclay incorporation. Abstract: Three-dimensional (3D) printing offers a novel approach to manufacture repeatable personalized structures for mass customization in medical fields. Considering the resemblance of materials in composition and microstructure to biological tissues, polysaccharide-based hydrogel is a promising printing material. However, its long-term stability of structure has always been a problem. In this work, we showed a green nanocomposite printing ink based on 2, 2, 6, 6-tetramethylpiperidinyl-1-oxyl (TEMPO)-oxidized bacterial cellulose (TOBC), sodium alginate (SA) and laponite nanoclay (Xls). The TOBC/SA/Xls hydrogel prepared by the 3D printing ink not only exhibited structural stability, but also performed a long-term release behavior of protein which could be attractive in medical application of drug release, biomedical devices and tissue engineering.