Does acute peripheral trauma contribute to idiopathic adult-onset dystonia?. (February 2020)

• Record Type: Journal Article
• Authors: Ferrazzano, Gina; Lalli, Stefania; Silvestre, Francesco; Manganelli, Fiore; Di Biasio, Francesca; Marchese, Roberta; Demonte, Giulio; Santangelo, Domenico; Devigili, Grazia; Durastanti, Valentina; Turla, Marinella; Mazzucchi, Sonia; Petracca, Martina; Oppo, Valentina; Barbero, Pierangelo; Morgante, Francesca; Di Lazzaro, Giulia; Squintani, Giovanna; Modugno, Nicola; Defazio, Giovanni; Fabbrini, Giovanni; Erro, Roberto; Albanese, Alberto; Barone, Paolo; Zibetti, Maurizio; Esposito, Marcello; Pellicciari, Roberta; Avanzino, Laura; Bono, Francesco; Eleopra, Roberto; Bertolasi, Laura; Altavista, Maria Concetta; Cotelli, Maria Sofia; Ceravolo, Roberto; Scaglione, Cesa; Bentivoglio, Anna Rita; Cossu, Giovanni; Coletti Moja, Mario; Girlanda, Paolo; Misceo, Salvatore; Pisani, Antonio; Mascia, Marcello Mario; Ercoli, Tommaso; Tinazzi, Michele; Maderna, Luca; Minafra, Brigida; Magistrelli, Luca; Romano, Marcello; Aguggia, Marco; Tambasco, Nicola; Castagna, Anna; Cassano, Daniela; Berardelli, Alfredo;
• Is Part Of: Parkinsonism & related disorders. Volume 71(2020)
• Page Start: 40
• Page End: 43
• Publication Date: 2020-02
• Subjects: Dystonia -- Trauma -- Injury; Parkinson's disease -- Periodicals; Movement disorders -- Periodicals; Movement Disorders -- Periodicals; Nerve Degeneration -- Periodicals; Nervous System Diseases -- Periodicals; Parkinson Disease -- Periodicals; Tremor -- Periodicals; Parkinson, Maladie de -- Périodiques; Parkinson's disease; 616.833
• DOI: 10.1016/j.parkreldis.2020.01.002
• Languages: English
• ISSNs: 1353-8020

Abstract

Abstract: Background: Acute peripheral trauma is a controversial risk factor for idiopathic dystonia. Materials and methods: We retrospectively analyzed data from the Italian Dystonia Registry regarding the occurrence of acute peripheral trauma severe enough to require medical attention in 1382 patients with adult-onset idiopathic dystonia and 200 patients with acquired adult-onset dystonia. Results: Patients with idiopathic and acquired dystonia showed a similar burden of peripheral trauma in terms of the number of patients who experienced trauma (115/1382 vs. 12/200, p = 0.3) and the overall number of injuries (145 for the 1382 idiopathic patients and 14 for the 200 patients with secondary dystonia, p = 0.2). Most traumas occurred before the onset of idiopathic or secondary dystonia but only a minority of such injuries (14 in the idiopathic group, 2 in the acquired group, p = 0.6) affected the same body part as that affected by dystonia. In the idiopathic group, the elapsed time between trauma and dystonia onset was 8.1 ± 9.2 years; only six of the 145 traumas (4.1%) experienced by 5/1382 idiopathic patients (0.36%) occurred one year or less before dystonia onset; in the acquired dystonia group, the two patients experienced prior trauma to the dystonic body part 5 and 6 years before dystonia development. Discussion and conclusion: Our data suggest that the contribution of peripheral acute trauma to idiopathic dystonia is negligible, if anything, and likely involves only a small subset of patients. Highlights: Acute peripheral trauma is a controversial risk factor for idiopathic dystonia. The role of trauma in idiopathic dystonia has relevant implications. The contribution of peripheral acute trauma to idiopathic dystonia is negligible.