INO80 and SWR1 complexes: the non-identical twins of chromatin remodelling. (April 2020)

• Record Type: Journal Article
• Authors: Willhoft, Oliver; Wigley, Dale B
• Is Part Of: Current opinion in structural biology. Volume 61(2020)
• Page Start: 50
• Page End: 58
• Publication Date: 2020-04
• Subjects: Molecular biology -- Periodicals; 570
• DOI: 10.1016/j.sbi.2019.09.002
• Languages: English
• ISSNs: 0959-440X

Abstract

Abstract : The INO80 family of chromatin remodellers are multisubunit complexes that perform a variety of tasks on nucleosomes. Family members are built around a heterohexamer of RuvB-like protein, an ATP-dependent DNA translocase, nuclear actin and actin-related proteins, and a few complex-specific subunits. They modify chromatin in a number of ways including nucleosome sliding and exchange of variant histones. Recent structural information on INO80 and SWR1 complexes has revealed similarities in the basic architecture of the complexes. However, structural and biochemical data on the complexes bound to nucleosomes reveal these similarities to be somewhat superficial and their biochemical activities and mechanisms are very different. Consequently, the INO80 family displays a surprising diversity of function that is based upon a similar structural framework.