Bisphenol A and the Risk of Obesity a Systematic Review With Meta-Analysis of the Epidemiological Evidence. Issue 2 (7th April 2020)

• Record Type: Journal Article
• Authors: Wu, Wentao; Li, Minmin; Liu, Amin; Wu, Chenlu; Li, Daning; Deng, Qiwei; Zhang, Binyan; Du, Jiaoyang; Gao, Xiangyu; Hong, Yan
• Is Part Of: Dose-response. Volume 18:Issue 2(2020)
• Publication Date: 2020-04-07
• Subjects: BPA/bisphenol A -- obesity -- child health -- public health -- meta-analysis; Dose-response relationship (Biochemistry) -- Periodicals; Drugs -- Dose-response relationship -- Periodicals; Drugs -- Physiological effect -- Periodicals; Hormesis -- Periodicals; Dose-Response Relationship, Drug -- Periodicals; Dose-response relationship (Biochemistry); Drugs -- Dose-response relationship; Drugs -- Physiological effect; Periodicals; 571.634
• DOI: 10.1177/1559325820916949
• Languages: English
• ISSNs: 1559-3258

Abstract

Bisphenol A (BPA) is suspected to be associated with several chronic metabolic diseases. The aim of the present study was to review previous epidemiological studies that examined the relationship between BPA exposure and the risk of obesity. PubMed, Web of Science, and Embase databases were systematically searched by 2 independent investigators for articles published from the start of database coverage until January 1, 2020. Subsequently, the reference list of each relevant article was scanned for any other potentially eligible publications. We included observational studies published in English that measured urinary BPA. Odds ratios with corresponding 95% confidence intervals for the highest versus lowest level of BPA were calculated. Ten studies with a sample size from 888 to 4793 participants met our inclusion criteria. We found a positive correlation between the level of BPA and obesity risk. A dose–response analysis revealed that 1-ng/mL increase in BPA increased the risk of obesity by 11%. The similar results were for different type of obesity, gender, and age.