Novel atlas of fiber directions built from ex-vivo diffusion tensor images of porcine hearts. (April 2020)

• Record Type: Journal Article
• Authors: Mojica, Mia; Pop, Mihaela; Sermesant, Maxime; Ebrahimi, Mehran
• Is Part Of: Computer methods and programs in biomedicine. Volume 187(2020)
• Publication Date: 2020-04
• Subjects: Cardiac atlas -- MRI -- Diffusion tensor imaging -- Elastic registration -- Tensor transformation; Medicine -- Computer programs -- Periodicals; Biology -- Computer programs -- Periodicals; Computers -- Periodicals; Medicine -- Periodicals; Médecine -- Logiciels -- Périodiques; Biologie -- Logiciels -- Périodiques; Biology -- Computer programs; Medicine -- Computer programs; Periodicals; Electronic journals; 610.28
• DOI: 10.1016/j.cmpb.2019.105200
• Languages: English
• ISSNs: 0169-2607

Abstract

Highlights: MR image-based predictive models of cardiac anatomy and fiber orientations can aid in better diagnosis of cardiovascular disease. In our work, we successfully constructed the first statistical cardiac fiber atlas for porcine hearts. An average cardiac geometry was computed from a small database via a computationally efficient algorithm. Local fiber directions were preserved in the computation of the average diffusion tensor field. Cross-validation statistics indicate that the constructed atlas can accurately describe the fiber architecture of a healthy pig heart. Abstract: Cardiac MR image-based predictive models integrating statistical atlases of heart anatomy and fiber orientations can aid in better diagnosis of cardiovascular disease, a major cause of death worldwide. Such atlases have been built from diffusion tensor (DT) images and can be used in anisotropic models for personalized computational electro-mechanical simulations when the fiber directions from DTI are not available. In this paper, we propose a framework for building the first statistical fiber atlas from high-resolution ex-vivo DT images of porcine hearts. A mean geometry that represents the average cardiac morphology of the dataset was first generated via groupwise registration. Then, the associated average cardiac fiber architecture was mapped out by computing the mean of the transformed DT fields of the subjects. To evaluate the stability of the atlas, we performed leave-one-out cross-validation. The resulting tensor statistics indicate that the fiber atlas could accurately describe the fiber architecture of a healthy pig heart.