Anticancer activity and X-ray structure determination of gold(I) complexes of 2-(diphenylphosphanyl)-1-aminocyclohexane. (1st June 2020) - Sulaiman, Adam A.
Graphical abstract: Effect of concentration of the gold(I) complexes (1 –4 ) and cisplatin on the percentage viability of A549, HeLa and HepG2 cancer cell lines. ORTEP diagram of complex 1 with the partial atomic labelling scheme, showing 30% probability ellipsoids. Highlights: Phosphane gold(I) complexes were synthesized and characterized. The in vitro cytotoxicity of the complexes was evaluated against three cancer cell lines: A549, HeLa and HepG2. Three of the four complexes showed excellent in vitro cytotoxicity; their inhibition effect is much greater than cisplatin. Abstract: Phosphane gold(I) complexes, [Au(ACP)Cl] (1 ) and [Au(ACP)(S2 CNR2 )] (2 –4 ) where ACP = 2-(diphenylphosphanyl)-1-aminocyclohexane or (2-aminocyclohexyl)diphenylphosphane, and R = methyl, ethyl, benzyl, were synthesized and characterized by elemental analysis, FTIR and multinuclear NMR spectroscopy. The molecular structure of one of the compounds, [Au(ACP)Cl] (1 ), was determined by single crystal X-ray diffraction analysis, which revealed a linear geometry around the Au(I) center. The crystal structure is stabilized by N–H⋯Cl hydrogen bonding interactions. The in vitro cytotoxicity of the complexes was evaluated against three cancer cells, A549 (human lung cancer), HeLa (human cervical cancer) and HepG2 (human liver cancer) cell lines. Three of the four complexes showed excellent in vitro cytotoxicity; their inhibition effect is much greater than that of cisplatin.