ZnI2-catalyzed carbocyclization of arylalkynes leads to the synthesis of polysubstituted dihydro- and tetrahydroquinoline derivatives. Issue 25 (18th June 2020)

• Record Type: Journal Article
• Authors: Cai, Xiaochen; Pan, Yongjie; Wang, Chaoyang; Qian, Guoying; Rong, Zhouting
• Is Part Of: Tetrahedron letters. Volume 61:Issue 25(2020)
• Publication Date: 2020-06-18
• Subjects: Zinc catalysis -- Alkyne activation -- Carbocyclization -- Dihydro- and tetrahydroquinoline derivatives; Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1016/j.tetlet.2020.151993
• Languages: English
• ISSNs: 0040-4039

Abstract

Graphical abstract: Highlights: Development of a novel zinc-catalyzed carbocyclization. A cheap and facile access to various dihydro- and tetrahydroquinolines. Formation of up to 3 carbon–carbon bonds in a single step. Abstract: A ZnI2 -catalyzed carbocyclization of arylalkynes has been developed for the construction of various polysubstituted dihydro- and tetrahydroquinoline derivatives. This inexpensive method extends the potential of zinc catalysis to the formation of up to three carbon–carbon bonds and three new rings in a single step with high diastereoselectivity.