Towards the objective assessment of suicidal states: Some neurocognitive deficits may be temporally related to suicide attempt. (May 2020)

• Record Type: Journal Article
• Authors: Interian, Alejandro; Myers, Catherine E.; Chesin, Megan S.; Kline, Anna; Hill, Lauren St.; King, Arlene R.; Miller, Rachael; Latorre, Miriam; Gara, Michael A.; Stanley, Barbara H.; Keilp, John G.
• Is Part Of: Psychiatry research. Volume 287(2020)
• Publication Date: 2020-05
• Subjects: Psychiatry -- Periodicals; Psychiatry -- periodicals; Psychiatrie -- Périodiques; 616.89
• DOI: 10.1016/j.psychres.2019.112624
• Languages: English
• ISSNs: 0165-1781

Abstract

Highlights: Response inhibition task performance is associated with suicide attempt recency. Recognition memory task performance is associated with suicide attempt recency. Effects for both neurocognitive tasks were independent of common suicide factors. Abstract: Neurocognitive detection of suicidal states has the potential to significantly advance objective risk assessment. This goal requires establishing that neurocognitive deficits fluctuate around the time of a suicide attempt. The current study therefore evaluated whether neurocognitive performance is temporally related to suicide attempt, in a sample at highrisk for suicide ( n = 141). Evaluations consisted of a clinician-administered interview, self-report questionnaires, and neurocognitive tasks assessing response inhibition, attentional control, and memory recognition. Analyses examined whether neurocognitive scores significantly differed according to the following temporal suicide attempt categories: (a) past-week attempt; (b) past-year attempt (not in past week); and (c) no past-year attempt. Univariate results showed that response inhibition and memory recognition were significantly related to suicide attempt recency. Post-hoc pairwise tests showed that participants with a past-week suicide attempt showed greater impairments than those without a past-year attempt. Multivariate tests showed the same pattern of results, adjusting for age, suicide attempts prior to past year, mood disturbance, and suicidal ideation. These results show that neurocognitive assessment of response inhibition and memory recognition shows sensitivity to the recency of a suicide attempt. While future prospective studies are needed, results suggest that phasic neurocognitive deficits may serve as objective markers of short-term suicide risk.