Investigation of DNA binding and bioactivities of thioether containing Schiff base Copper(II), Cobalt(II) and Palladium(II) complexes: Synthesis, characterization, spectrochemical study, viscosity measurement. (1st July 2020)

• Record Type: Journal Article
• Authors: Maiti, Subir Kr; Kalita, Mukul; Singh, Anmol; Deka, Jahnabi; Barman, Pranjit
• Is Part Of: Polyhedron. Volume 184(2020)
• Publication Date: 2020-07-01
• Subjects: Thioether -- Schiff base -- Metal complex -- XRD -- Crystal structure -- DNA binding -- Bioactivity; Chemistry, Inorganic -- Periodicals; Chimie inorganique -- Périodiques; Organometaalverbindingen; Anorganische chemie; 546.05
• DOI: 10.1016/j.poly.2020.114559
• Languages: English
• ISSNs: 0277-5387

Abstract

Graphical abstract: Abstract: Three complexes of an ONS donor ligand of the Schiff base [C21 H19 NO2 S] (HL ), [Cu(C21 H18 NO2 S)2 ] (1) [Co(C21 H18 NO2 S)2 ] (2 ) and [Pd(C21 H18 NO2 SCl)] (3), were synthesized and characterized by elemental analysis, FT-IR, 1 H NMR, UV–Visible spectroscopy and single-crystal X-ray diffraction analysis. Single crystal X-ray diffraction analysis reveals that the copper complex acquires a distorted pyramidal structure and the palladium complex acquires a square planar structure. All the compounds are stable at room temperature and they show very good antibacterial activities against gram-positive and gram-negative bacteria. DNA binding activities of the ligand and its Cu(II), Pd(II) and Co(II) complexes with CT-DNA were carried out in DMF and tris-buffer (5 mM, pH 7.3) solution; all the three complexes along with the ligand show a very good intercalative mode of DNA interaction with Kb values of 1.56(±0.03) × 10 5 for 1 and 1.02(±0.09) × 10 5 for 3 . The DNA binding activity has also been confirmed by a hydrodynamic study (viscosity). The order of DNA binding activity is 1 > 3 > 2 .