Lipase-Catalyzed Synthesis of Sn-2 Palmitate: A Review. (April 2020)

• Record Type: Journal Article
• Authors: Wei, Wei; Sun, Cong; Wang, Xiaosan; Jin, Qingzhe; Xu, Xuebing; Akoh, Casimir C.; Wang, Xingguo
• Is Part Of: Engineering. Volume 6:Number 4(2020)
• Page Start: 406
• Page End: 414
• Publication Date: 2020-04
• Subjects: Structured triacylglycerols -- Palmitic acid -- Human milk fat substitutes -- Lipase-catalyzed reaction -- Sn-2 palmitate -- Quantitative analysis; Engineering -- Periodicals; Engineering -- China -- Periodicals; 620.005
• DOI: 10.1016/j.eng.2020.02.008
• Languages: English
• ISSNs: 2095-8099

Abstract

Abstract: Human milk fat (HMF) is an important source of nutrients and energy for infants. Triacylglycerols (TAGs) account for about 98% of HMF and have a unique molecular structure. HMF is highly enriched in palmitic acid (PA) at the sn -2 position of the glycerol backbone (more than 70%) and in unsaturated fatty acids at the sn -1, 3 position. The specific TAG structure in HMF plays a valuable function in infant growth. Sn -2 palmitate (mainly 1, 3-dioleoyl-2-palmitoyl-glycerol) is one of the structured TAGs that is commonly supplemented into infant formula in order to enable it to present a similar structure to HMF. In this review, the development of the lipase-catalyzed synthesis of sn -2 palmitate over the last 25 years are summarized, with a focus on reaction schemes in a laboratory setting. Particular attention is also paid to the commercialized sn -1, 3 regioselective lipases that are used in structured TAGs synthesis, to general methods of TAG analysis, and to successfully developed sn -2 palmitate products on the market. Prospects for the lipase-catalyzed synthesis of sn -2 palmitate are discussed.