Subtelomeric Transcription and its Regulation. Issue 15 (10th July 2020)

• Record Type: Journal Article
• Authors: Kwapisz, Marta; Morillon, Antonin
• Is Part Of: Journal of molecular biology. Volume 432:Issue 15(2020)
• Page Start: 4199
• Page End: 4219
• Publication Date: 2020-07-10
• Subjects: subtelomeres -- noncoding RNA -- repeated sequences -- transcription; Molecular biology -- Periodicals; Biology -- Periodicals; Biochemistry -- Periodicals; Bacteriology -- Periodicals; Molecular Biology -- Periodicals; Biochemistry -- Periodicals; Biologie moléculaire -- Périodiques; Biologie -- Périodiques; Biochimie -- Périodiques; Moleculaire biologie; Biochemistry; Biology; Molecular biology; Periodicals; 572.805
• DOI: 10.1016/j.jmb.2020.01.026
• Languages: English
• ISSNs: 0022-2836

Abstract

Abstract: The subtelomeres, highly heterogeneous repeated sequences neighboring telomeres, are transcribed into coding and noncoding RNAs in a variety of organisms. Telomereproximal subtelomeric regions produce non-coding transcripts i.e., ARRET, αARRET, subTERRA, and TERRA, which function in telomere maintenance. The role and molecular mechanisms of the majority of subtelomeric transcripts remain unknown. This review depicts the current knowledge and puts into perspective the results obtained in different models from yeasts to humans. Graphical abstract: Image 1 Highlights: The subtelomeres are highly heterogeneous repeated sequences next to telomeres. They are transcribed into coding and noncoding (nc)RNAs in a variety of organisms. The subtelomeric ncRNAs ARRET, αARRET, subTERRA and TERRA maintain telomere. But the role and molecular mechanisms of most of subtelomeric RNA remain unknown. This review puts into perspective different model organisms, from yeasts to humans.