Different findings of morphological changes and functional decline in the vestibule and the semicircular canal in ipsilateral delayed endolymphatic hydrops. Issue 7 (July 2020)

• Record Type: Journal Article
• Authors: Yu, Jing; Zhou, Yu-Juan; Xu, Xin-Da; Tian, Liang; Ren, Dong-Dong; Ding, Chen-Ru; Wang, Jing; Chi, Fang-Lu
• Is Part Of: Clinical neurophysiology. Volume 131:Issue 7(2020:Jul.)
• Page Start: 1487
• Page End: 1494
• Publication Date: 2020-07
• Subjects: Delayed endolymphatic hydrops -- Endolymphatic hydrops -- Caloric test -- Vestibular evoked myogenic potentials -- Gadolinium-enhanced magnetic resonance imaging; Neurophysiology -- Periodicals; Electroencephalography -- Periodicals; Electromyography -- Periodicals; Neurology -- Periodicals; 612.8
• DOI: 10.1016/j.clinph.2020.03.032
• Languages: English
• ISSNs: 1388-2457

Abstract

Highlights: Hydrops can be found mainly in the vestibule as shown by MRI. In the vestibule, abnormalities are commonly morphologic rather than functional. In the lateral semicircular canal, a functional deterioration can be detected more frequently than morphological changes. Abstract: Objective: To elucidate the pathophysiological process by analyzing the correlation between morphological and functional changes in patients with delayed endolymphatic hydrops (DEH). Methods: Twenty-nine patients diagnosed with DEH were enrolled in this retrospective study. All patients were assessed using the caloric test, cervical and ocular vestibular evoked myogenic potentials, and gadolinium-enhanced magnetic resonance imaging (MRI) of the inner ear. Results: According to the MRI, the hydrops localization was categorized as hydrops in the vestibule (saccule and utricle) (14%), hydrops in the vestibule and cochlea (72%), and hydrops in the vestibule, cochlea, and lateral semicircular canal (LSCC) (14%). Vestibular hydrops could definitely be observed as function declined; however, a dysfunction of both the saccule and utricle was not always present when vestibular hydrops was detected with MRI. In the LSCC, a decline in functional tests was not necessarily accompanied by morphological abnormalities. However, dysfunction could definitely be detected when LSCC hydrops was observed with MRI. Conclusions: Hydrops can be found mainly in the vestibule as shown by MRI. In the vestibule, abnormalities are commonly morphologic rather than functional, whereas in the LSCC a functional deterioration can be detected more frequently than morphological changes. Significance: Our findings can provide a new perspective on the functional and morphological characteristics of patients with DEH.