Excessive fluoride exposure induces thymocyte apoptosis and impairs cell division: Roles of the PERK and IRE1 pathways. (1st August 2020)

• Record Type: Journal Article
• Authors: Wei, Wei; Wang, Qian; Pang, Shujuan; Tan, Shiwen; Sun, Jing; Li, Mengdi; Wang, Shize; Sun, Dianjun
• Is Part Of: Toxicology letters. Volume 328(2020)
• Page Start: 35
• Page End: 44
• Publication Date: 2020-08-01
• Subjects: Toxicology -- Periodicals; 363.179
• DOI: 10.1016/j.toxlet.2020.04.014
• Languages: English
• ISSNs: 0378-4274

Abstract

Highlights: Excessive fluoride inhibited division and induced apoptosis of thymocytes. Excessive fluoride induced activation of PERK and IRE1 signaling in thymocytes. PERK and IRE1 signaling induced by fluoride plays a key role in immunosuppression.