Clinical significance of arterial stiffness as a factor for hospitalization of heart failure with preserved left ventricular ejection fraction: a retrospective matched case-control study. Issue 2 (August 2020)

• Record Type: Journal Article
• Authors: Takagi, Koji; Ishihara, Shiro; Kenji, Nakama; Iha, Hayano; Kobayashi, Noriyuki; Ito, Yusuke; Nohara, Tsuyoshi; Ohkuma, Satoru; Mitsuishi, Tatsuya; Ishizuka, Atsushi; Shigihara, Shota; Sone, Michiko; Tokuyama, Hideo; Omote, Toshiya; Kikuchi, Arifumi; Nakamura, Shunichi; Yamamoto, Eisei; Ishikawa, Masahiro; Amitani, Kenichi; Takahashi, Naoto; Maruyama, Yuji; Imura, Hajime; Sato, Naoki; Shimizu, Wataru
• Is Part Of: Journal of cardiology. Volume 76:Issue 2(2020)
• Page Start: 171
• Page End: 176
• Publication Date: 2020-08
• Subjects: Heart failure with preserved left ventricular ejection fraction -- Arterial stiffness -- Cardio-ankle vascular index -- Risk factor -- Retrospective matched case-control study; Cardiology -- Periodicals; 616.12
• DOI: 10.1016/j.jjcc.2020.02.013
• Languages: English
• ISSNs: 0914-5087

Abstract

Highlights: Cardio-ankle vascular index (CAVI) indicates arterial stiffness. Patients hospitalized with heart failure with preserved left ventricular ejection fraction (HFpEF) showed high values of CAVI. High value of CAVI was associated with hospitalization of HFpEF patients. It remains unknown whether modulating CAVI prevents the development of HFpEF. Abstract: Background: Previous studies have been conducted to identify characteristics of patients with heart failure with preserved ejection fraction (HFpEF), but the risk factors of HFpEF remain unclear. We investigated the associations between arterial stiffness and the risk of hospitalization for HFpEF patients. Methods: For the case group, we enrolled patients with preserved EF who had been hospitalized for HF from April 2013 to March 2015 and examined the cardio-ankle vascular index (CAVI). For the control group, we enrolled outpatients with preserved EF and with hypertension, diabetes mellitus, dyslipidemia, and/or coronary artery disease but who did not present with HF symptoms and had never been diagnosed or treated for HF during the same period. The control group matched with the case group for age and sex. The association between hospitalized HFpEF and clinical variables was analyzed using conditional logistic regression models. Results: The CAVI value was significantly higher in patients with hospitalized HFpEF compared with patients with the control [10.4 (9.8–11.0) vs. 9.2 (8.1–10.0), p < 0.001). On the multivariate conditional logistic regression analysis, high CAVI (OR 6.76, 95% CI 2.28–20.10, p < 0.001) and anemia (OR 3.91, 95% CI 1.47–10.40, p = 0.006) were independently associated with hospitalization of HFpEF patients. Conclusions: The present study has demonstrated that the high value of CAVI was independently associated with the hospitalization of HFpEF patients.