Cyclodextrin as a magic switch in covalent and non-covalent anticancer drug release systems. (15th August 2020)

• Record Type: Journal Article
• Authors: Tian, Bingren; Liu, Yumei; Liu, Jiayue
• Is Part Of: Carbohydrate polymers. Volume 242(2020)
• Publication Date: 2020-08-15
• Subjects: 5-FU 5-Fluorouracil -- 5-FUA 5-Fluorouracil-1-acetic acid -- ASGPR Asialoglycoprotein receptor -- ATRT All-trans-retinoic acid -- BBR Berberine -- CA Competing agent -- CD Cyclodextrin -- CPT Camptothecin -- CUR Curcumin -- DOX Doxorubicin -- FA Ferulic acid -- FdUrd 5-Fluoro-2′-deoxyuridine -- GAP Azobenzene/galactose grafted polymer -- GPI Glycosylphosphatidylinositol -- HP-β-CD Hydroxypropyl-β-cyclodextrin -- MDR Multidrug resistance -- MSN Mesoporous silica nanoparticles -- M-β-CD Methyl-β-cyclodextrin -- OXY Oxyresveratrol -- PTX Paclitaxel -- RNase Ribonuclease A -- SBE-β-CD Sulfobutyl-β-cyclodextrin -- SCU Scutellarin -- THPP 510, 15, 20-Tetrakis(4-hydroxyphenyl)porphyrin -- α-CD α-Cyclodextrin -- β-CD β-Cyclodextrin -- γ-CD γ-Cyclodextrin; Cyclodextrin -- Anticancer drug -- Controlled release -- System -- Mechanism -- Application; Polysaccharides -- Periodicals; Polysaccharides -- Periodicals; Polysaccharides -- Périodiques; Electronic journals; 547.78
• DOI: 10.1016/j.carbpol.2020.116401
• Languages: English
• ISSNs: 0144-8617

Abstract

Graphical abstract: Highlights: The roles of CD are reviewed in controlled release of anticancer drugs. Different CD controlled release systems and mechanisms are classified. The opportunity and future challenge for CD as a magic switch are discussed. Abstract: Cancer has been a threat to human health, so its treatment is a huge challenge to the present medical field. One of commonly used methods is the controlled release of anticancer drug to reduce the dose for patients, increase the stability of drug treatment and minimize side effects. Cyclodextrin is a kind of cyclic oligosaccharide produced by amylase hydrolysis. Because cyclodextrin contains a cavity structure and active hydroxyl groups, it has a positive effect on the study of the controlled release of anticancer drugs. This article reviews the controlled release of current anticancer drugs based on cyclodextrins as a "flexible switch", and discusses the classification of different types of release systems, highlighting their role in cancer treatment. Moreover, the opportunities and challenges of cyclodextrin as a magic switch in the controlled release of anticancer drugs are discussed.